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The possible role of inorganic thiophosphate as a prebiotic phosphorylating agent
- Source :
- Journal of molecular evolution. 3(4)
- Publication Year :
- 1974
-
Abstract
- It is proposed that inorganic thiophosphate was a versatile and highly reactive constituent of the primitive earth. Some of the ramifications of this assumption with regard to prebiotic chemistry stem from the dual nature of thiophosphate as the most superior nucleophilic agent and an energy rich phosphate. The Michael addition of thiophosphate to acrylonitrile yieldsS-cyanoethylphosphorothioate in high yield. This compound in turn can be used to phosphorylate 2′-deoxythymidine in organic solvents and in the solid state. A mixture of 5′ and 3′-dTMP were identified via chromatography, elementary analysis and NMR spectroscopy.
- Subjects :
- Nucleosides
Nuclear magnetic resonance spectroscopy
Biology
Phosphate
Biological Evolution
Thiophosphate
Phosphates
Turn (biochemistry)
chemistry.chemical_compound
chemistry
Biochemistry
Nucleophile
Models, Chemical
Yield (chemistry)
Genetics
Michael reaction
Organic chemistry
Acrylonitrile
Molecular Biology
Ecology, Evolution, Behavior and Systematics
Thymidine
Subjects
Details
- ISSN :
- 00222844
- Volume :
- 3
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Journal of molecular evolution
- Accession number :
- edsair.doi.dedup.....f2a62a5a204dce6bd657c8704bd3686e