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It Is High Time for Personalized Dietary Counseling in Celiac Disease: A Systematic Review and Meta-Analysis on Body Composition
- Source :
- Nutrients, Vol 13, Iss 2947, p 2947 (2021), Nutrients
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- The body composition of patients with celiac disease (CD), on which the effects of a gluten-free diet (GFD) are controversial, differs from that of the average population. In this study, we aimed to compare the body composition across CD patients before a GFD, CD patients after a one-year GFD and non-celiac control subjects. A systematic search was conducted using five electronic databases up to 15 July 2021 for studies that reported at least one of the pre-specified outcomes. In meta-analyses, weighted mean differences (WMDs) with 95% confidence intervals (CIs) were calculated. A total of 25 studies were eligible for systematic review, seven of which were included in meta-analysis. During a ≥1-year GFD, fat mass of CD patients, compared to that at baseline, significantly increased (WMD = 4.1 kg, 95% CI = 1.5 to 6.6, three studies). In CD patients after a ≥1-year GFD, compared to non-celiac controls, fat mass (WMD = −5.8 kg, 95% CI = −8.7 to −2.9, three studies) and fat-free mass (WMD = −1.9 kg, 95% CI = −3.0 to −0.7, three studies) were significantly lower. In conclusion, body composition-related parameters of CD patients differ from that of the non-celiac control subjects even after a longstanding GFD.
- Subjects :
- Counseling
medicine.medical_specialty
Databases, Factual
Population
Review
Disease
Fat mass
Diet, Gluten-Free
gluten-free diet
Dietary counseling
Internal medicine
medicine
Humans
TX341-641
Precision Medicine
education
body composition
education.field_of_study
Nutrition and Dietetics
Nutrition. Foods and food supply
business.industry
Control subjects
Confidence interval
Adipose Tissue
Meta-analysis
business
celiac disease
Food Science
Systematic search
Subjects
Details
- ISSN :
- 20726643
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Nutrients
- Accession number :
- edsair.doi.dedup.....f2a051b7cd2f81197f9eb105b4b76032