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Ductal carcinoma in situ of the breast in younger women: a subgroup of patients at high risk
- Source :
- EJSO-European Journal of Surgical Oncology, EJSO-European Journal of Surgical Oncology, WB Saunders, 2010, 36 (12), pp.1165. ⟨10.1016/j.ejso.2010.09.001⟩, EJSO-European Journal of Surgical Oncology, 2010, 36 (12), pp.1165. ⟨10.1016/j.ejso.2010.09.001⟩
- Publication Year :
- 2010
-
Abstract
- Background After breast conservative treatment (BCT), young age is a predictive factor for recurrence in patients with Ductal Carcinoma In Situ (DCIS) of the breast. The purpose of this study was to evaluate predictive factors for recurrence and outcomes in these younger women (under 40 years) treated for pure DCIS. Methods From 1974 to 2003, 207 cases were collected in 12 French Cancer Centers. Median age was 36.3 years and median follow-up 160 months. Seventy four (35.8%) underwent mastectomy, 67 (32.4%) lumpectomy alone and 66 (31.9%) lumpectomy plus radiotherapy. Results 37 recurrences occurred (17.8%): 14 (38%) were in situ and 23 (62%) invasive. After BCT, the overall rate of recurrence was 27% (33% in the lumpectomy plus radiotherapy group vs. 21% in the lumpectomy alone group). Comedocarcinoma subtype ( p = 0.004), histological size more than 10 mm ( p = 0.011), necrosis ( p = 0.022) and positive margin status ( p = 0.019) were statistically significant predictive factors for recurrence. The actuarial 15-year rates of local recurrence were 29%, 42% and 37% in the lumpectomy alone, lumpectomy and whole breast radiotherapy and lumpectomy + whole breast radiotherapy with additional boost groups respectively. After recurrence, the 10-year overall survival rate was 67.2%. Conclusion High recurrence rates (mainly invasive) after BCT in young women with DCIS are confirmed. BCT in this subgroup of patients is possible if clear and large margins are obtained, tumor size is under 11 mm and necrosis- and/or comedocarcinoma-free.
- Subjects :
- medicine.medical_treatment
comedocarcinoma
Kaplan-Meier Estimate
Mastectomy, Segmental
radiation therapy
0302 clinical medicine
Risk Factors
ductal carcinoma in situ
030212 general & internal medicine
skin and connective tissue diseases
margin status
relapse
Lumpectomy
Carcinoma, Ductal, Breast
Age Factors
General Medicine
Prognosis
3. Good health
Oncology
030220 oncology & carcinogenesis
Predictive value of tests
Female
Radiology
France
local recurrence
Comedocarcinoma
Mastectomy
Carcinoma in Situ
Adult
medicine.medical_specialty
Breast surgery
Breast Neoplasms
Risk Assessment
Disease-Free Survival
03 medical and health sciences
Mastectomy, Modified Radical
Predictive Value of Tests
young age
medicine
Carcinoma
Humans
neoplasms
breast
& cancer survival
Patient Care Team
business.industry
Ductal carcinoma
medicine.disease
Surgery
body regions
Radiation therapy
Radiotherapy, Adjuvant
Neoplasm Recurrence, Local
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 15322157 and 07487983
- Volume :
- 36
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
- Accession number :
- edsair.doi.dedup.....f295193a79596fe864d63967c7ea0e09