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Clinical significance of CCBE1 expression in lung cancer
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2017
- Publisher :
- Spandidos Publications, 2017.
-
Abstract
- Lymph node metastasis (LNM) is one of the major causes of cancer-associated morbidity and mortality in patients with lung cancer following radical pulmonary carcinoma resection. The present study aimed to investigate the relationship between the expression of collagen and calcium-binding epidermal growth factor domain-containing protein 1 (CCBE1) and lymphatic vessel endothelial hyaluronan receptor 1 (LYVE1) in tumor tissue with the clinical prognosis of lung cancer. The present study included 40 patients with lung cancer that underwent pulmonary carcinoma resection, including 10 patients with LNM, and 10 control patients who underwent pulmonary bullae resection. CCBE1 and LYVE1 expression was assessed in samples from normal and tumor tissue using polymerase chain reaction, western blot analysis and immunohistochemistry. CCBE1 expression appeared to be decreased in lung tumor tissue and further downregulated in samples from patients with LNM, and was revealed to be correlated with poor clinical outcome. Conversely, LYVE1 expression appeared to be upregulated in lung cancer tissue. In conclusion, the present results suggested that CCBE1 and LYVE1 may have potential as biomarkers for the identification of lung cancer patients at a high risk of LNM.
- Subjects :
- Male
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Lung Neoplasms
Vesicular Transport Proteins
Gene Expression
Kaplan-Meier Estimate
Biochemistry
03 medical and health sciences
0302 clinical medicine
Recurrence
Epidermal growth factor
Internal medicine
Biomarkers, Tumor
Genetics
Lymphatic vessel
Humans
Medicine
Clinical significance
Neoplasm Metastasis
Lung cancer
Molecular Biology
Neoplasm Staging
lymph node metastasis
Oncogene
business.industry
Tumor Suppressor Proteins
Calcium-Binding Proteins
Cancer
Articles
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
lymphatic vessel endothelial hyaluronan receptor 1
Hyaluronan-mediated motility receptor
lung cancer
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Molecular Medicine
Female
business
collagen and calcium binding EGF domains 1
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....f2887d8577558c3ba7068302bcbc3974