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Zika Virus: Origins, Pathological Action, and Treatment Strategies
- Source :
- Frontiers in Microbiology, Frontiers in Microbiology, Vol 9 (2019)
- Publication Year :
- 2018
-
Abstract
- The Zika virus (ZIKV) global epidemic prompted the World Health Organization to declare it a 2016 Public Health Emergency of International Concern. The overwhelming experience over the past several years teaches us that ZIKV and the associated neurological complications represent a long-term world-wide challenge to public health. Although the number of ZIKV cases in the Western Hemisphere has dropped since 2016, the need for basic research and anti-ZIKV drug development remains strong. Re-emerging viruses like ZIKV are an ever-present threat in the 21st century where fast transcontinental travel lends itself to viral epidemics. Here, we first present the origin story for ZIKV and review the rapid progress researchers have made toward understanding of the ZIKV pathology and in the design, re-purposing, and testing-particularly in vivo-drug candidates for ZIKV prophylaxis and therapy ZIKV. Quite remarkably, a short, but intensive, drug-repurposing effort has already resulted in several readily available FDA-approved drugs that are capable of effectively combating the virus in infected adult mouse models and, most importantly, in both preventing maternal-fetal transmission and severe microcephaly in newborns in pregnant mouse models.
- Subjects :
- Microbiology (medical)
medicine.medical_specialty
Microcephaly
lcsh:QR1-502
Review
Microbiology
World health
lcsh:Microbiology
drugs
Zika virus
03 medical and health sciences
Basic research
maternal transmission
Medicine
Intensive care medicine
030304 developmental biology
ZIKV
Western hemisphere
0303 health sciences
biology
030306 microbiology
business.industry
Transmission (medicine)
Public health
re-purposing
medicine.disease
biology.organism_classification
3. Good health
in vivo
Treatment strategy
business
Subjects
Details
- ISSN :
- 1664302X
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Frontiers in microbiology
- Accession number :
- edsair.doi.dedup.....f28712fd79db44318e13950931ffd96c