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IL-7 induces immunological improvement in SIV-infected rhesus macaques under antiviral therapy
- Source :
- Journal of Immunology, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (2), pp.914-22. ⟨10.4049/jimmunol.176.2.914⟩, Journal of Immunology, 2006, 176 (2), pp.914-22. ⟨10.4049/jimmunol.176.2.914⟩
- Publication Year :
- 2006
- Publisher :
- HAL CCSD, 2006.
-
Abstract
- Despite efficient antiretroviral therapy (ART), CD4+ T cell counts often remain low in HIV-1-infected patients. This has led to IL-7, a crucial cytokine involved in both thymopoiesis and peripheral T cell homeostasis, being suggested as an additional therapeutic strategy. We investigated whether recombinant simian IL-7-treatment enhanced the T cell renewal initiated by ART in rhesus macaques chronically infected with SIVmac251. Six macaques in the early chronic phase of SIV infection received antiretroviral treatment. Four macaques also received a 3-wk course of IL-7 injections. Viral load was unaffected by IL-7 treatment. IL-7 treatment increased the number of circulating CD4+ and CD8+ memory T cells expressing activation (HLA-DR+, CD25+) and proliferation (Ki-67+) markers. It also increased naive (CD45RAbrightCD62L+) T cell counts by peripheral proliferation and enhanced de novo thymic production. The studied parameters returned to pretreatment values by day 29 after the initiation of treatment, concomitantly to the appearance of anti-IL-7 neutralizing Abs, supporting the need for a nonimmunogenic molecule for human treatment. Thus, IL-7, which increases T cell memory and de novo renewal of naive T cells may have additional benefits in HIV-infected patients receiving ART.
- Subjects :
- CD4-Positive T-Lymphocytes
medicine.medical_treatment
T cell
[SDV]Life Sciences [q-bio]
Immunology
Simian Acquired Immunodeficiency Syndrome
Biology
Simian
CD8-Positive T-Lymphocytes
Lymphocyte Activation
Antiviral Agents
law.invention
03 medical and health sciences
0302 clinical medicine
law
T-Lymphocyte Subsets
medicine
Immunology and Allergy
Animals
Humans
IL-2 receptor
Lymphocyte Count
Viremia
030304 developmental biology
Cell Proliferation
0303 health sciences
Base Sequence
Interleukin-7
DNA
biology.organism_classification
Virology
Macaca mulatta
Recombinant Proteins
3. Good health
Peripheral
Cytokine
medicine.anatomical_structure
Recombinant DNA
Viral load
CD8
030215 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 00221767 and 15506606
- Database :
- OpenAIRE
- Journal :
- Journal of Immunology, Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2006, 176 (2), pp.914-22. ⟨10.4049/jimmunol.176.2.914⟩, Journal of Immunology, 2006, 176 (2), pp.914-22. ⟨10.4049/jimmunol.176.2.914⟩
- Accession number :
- edsair.doi.dedup.....f272f0d6e797d913cbde5a85bb5b817e