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Artificially Reprogrammed Macrophages as TumorâTropic ImmunosuppressionâResistant Biologics to Realize Therapeutics Production and Immune Activation
- Source :
- Advanced Materials. 31:1807211
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- To engineer patient-derived cells into therapy-purposed biologics is a promising solution to realize personalized treatments. Without using gene-editing technology, a live cell-typed therapeutic is engineered for tumor treatment by artificially reprogramming macrophages with hyaluronic acid-decorated superparamagnetic iron oxide nanoparticles (HIONs). This nanoparticle-assisted cell-reprogramming strategy demonstrates profound advantages, due to the combined contributions from the biological regulation of HIONs and the intrinsic nature of macrophages. Firstly, the reprogrammed macrophages present a substantial improvement in their innate capabilities, such as more effective tumor targeting and more efficient generation of bioactive components (e.g., reactive oxygen species, bioactive cytokines) to suppress tumor growth. Furthermore, this cell therapeutic exhibits cytostatic/proapoptotic effects specific to cancer cells. Secondly, HIONs enable macrophages more resistant to the intratumoral immunosuppressive environment. Thirdly, the macrophages are endowed with a strong ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine-like manner. Consequently, a synergistic tumor-inhibition effect is achieved. This study shows that engineering nanomaterial-reprogrammed live cells as therapeutic biologics may be a more preferable option to the commonly used approaches where nanomaterials are administrated to induce bioresponse of certain cells in vivo.
- Subjects :
- Cytotoxicity, Immunologic
Materials science
medicine.medical_treatment
Cell
02 engineering and technology
010402 general chemistry
01 natural sciences
Mice
Antigens, Neoplasm
In vivo
Cell Line, Tumor
Neoplasms
Tumor Microenvironment
medicine
Animals
Humans
General Materials Science
Magnetite Nanoparticles
chemistry.chemical_classification
Mice, Inbred BALB C
Reactive oxygen species
Macrophages
Mechanical Engineering
Immunosuppression
Cellular Reprogramming
021001 nanoscience & nanotechnology
Phenotype
0104 chemical sciences
medicine.anatomical_structure
chemistry
Drug Resistance, Neoplasm
Mechanics of Materials
Cancer cell
Cancer research
Female
0210 nano-technology
Biological regulation
Reprogramming
Subjects
Details
- ISSN :
- 15214095 and 09359648
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Advanced Materials
- Accession number :
- edsair.doi.dedup.....f2640ff33384ca0cc1da70f076e9f7d5