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Assessment of quality of life on 4-year growth hormone therapy in Japanese patients with adult growth hormone deficiency: A post-marketing, multicenter, observational study
- Source :
- Growth Hormone & IGF Research. 36:36-43
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Objective Improvement of quality of life (QOL) by growth hormone (GH) therapy was not demonstrated in Japanese adult growth hormone deficiency (AGHD) patients by either the QOL Assessment of Growth Hormone Deficiency in Adults or the Questions on Life Satisfaction-Hypopituitarism, which are widely used to evaluate QOL in Western AGHD patients. We therefore evaluated QOL in Japanese AGHD patients receiving recombinant GH, Norditropin® (Novo Nordisk A/S, Denmark), using the newly developed Adult Hypopituitarism Questionnaire (AHQ). Design This multicenter, non-interventional, observational study in Japanese patients with severe AGHD was conducted from 1 October 2009 to 30 September 2014. Patients with severe AGHD already receiving somatropin and somatropin-naive patients were included. GH therapy (Norditropin®) was initiated as injections of 0.021 mg/kg/week divided into 6–7 doses/week, and was adjusted according to clinical responses. Demographic/clinical data were obtained from medical records or by patient recall. QOL was assessed using the AHQ at baseline; 3, 6, and 12 months; and annually up to 4 years. Results Of 387 registered patients, 161 were eligible for QOL analysis. AHQ scores significantly improved after 3 months of treatment. Improvements in the psycho-social and physical domains were statistically significant throughout the 4-year study period. Although the GH dose was increased in females such that insulin-like growth factor-1 levels reached those of males, QOL improvements in females did not reach those of males. Despite the greater GH dose in child-onset patients, limited QOL improvements were observed in child-onset vs adult-onset cases. Conclusions Four-year GH treatment in Japanese AGHD patients elicits sustained improvement in QOL as assessed by AHQ scores.
- Subjects :
- Adult
Male
0301 basic medicine
Pediatrics
medicine.medical_specialty
Hormone Replacement Therapy
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Hypopituitarism
Growth hormone
Growth hormone deficiency
03 medical and health sciences
0302 clinical medicine
Endocrinology
Quality of life
Product Surveillance, Postmarketing
Humans
Medicine
Growth Disorders
Human Growth Hormone
business.industry
Medical record
Objective Improvement
Middle Aged
medicine.disease
Recombinant Proteins
Somatropin
030104 developmental biology
Quality of Life
Female
Observational study
business
Subjects
Details
- ISSN :
- 10966374
- Volume :
- 36
- Database :
- OpenAIRE
- Journal :
- Growth Hormone & IGF Research
- Accession number :
- edsair.doi.dedup.....f25a08d904cf4b2acc6a44af0186bfab