Back to Search
Start Over
Estrogen receptor hormone agonists limit trauma hemorrhage shock-induced gut and lung injury in rats
- Source :
- PLoS ONE, Vol 5, Iss 2, p e9421 (2010), PLoS ONE
- Publication Year :
- 2010
- Publisher :
- Public Library of Science (PLoS), 2010.
-
Abstract
- Background Acute lung injury (ALI) and the development of the multiple organ dysfunction syndrome (MODS) is a major cause of death in trauma patients. Earlier studies in trauma hemorrhagic shock (T/HS) have documented that splanchnic ischemia leading to gut inflammation and loss of barrier function is an initial triggering event that leads to gut-induced ARDS and MODS. Since sex hormones have been shown to modulate the response to T/HS and proestrous (PE) females are more resistant to T/HS-induced gut and distant organ injury, the goal of our study was to determine the contribution of estrogen receptor (ER)alpha and ERbeta in modulating the protective response of female rats to T/HS-induced gut and lung injury. Methods/principal findings The incidence of gut and lung injury was assessed in PE and ovariectomized (OVX) female rats subjected to T/HS or trauma sham shock (T/SS) as well as OVX rats that were administered estradiol (E2) or agonists for ERalpha or ERbeta immediately prior to resuscitation. Marked gut and lung injury was observed in OVX rats subjected to T/HS as compared to PE rats or E2-treated OVX rats subjected to T/HS. Both ERalpha and ERbeta agonists were equally effective in limiting T/HS-induced morphologic villous injury and bacterial translocation, whereas the ERbeta agonist was more effective than the ERalpha agonist in limiting T/HS-induced lung injury as determined by histology, Evan's blue lung permeability, bronchoalevolar fluid/plasma protein ratio and myeloperoxidase levels. Similarly, treatment with either E2 or the ERbeta agonist attenuated the induction of the intestinal iNOS response in OVX rats subjected to T/HS whereas the ERalpha agonist was only partially protective. Conclusions/significance Our study demonstrates that estrogen attenuates T/HS-induced gut and lung injury and that its protective effects are mediated by the activation of ERalpha, ERbeta or both receptors.
- Subjects :
- Critical Care and Emergency Medicine
Estrogen receptor
Nitric Oxide Synthase Type II
lcsh:Medicine
Rats, Sprague-Dawley
0302 clinical medicine
polycyclic compounds
Shock, Traumatic
Receptor
lcsh:Science
0303 health sciences
Multidisciplinary
Estradiol
Chemistry
Lung Injury
Immunohistochemistry
3. Good health
Intestines
Ovariectomized rat
Female
hormones, hormone substitutes, and hormone antagonists
Research Article
Agonist
medicine.medical_specialty
medicine.drug_class
Multiple Organ Failure
Ovariectomy
Estrous Cycle
Lung injury
Shock, Hemorrhagic
03 medical and health sciences
Internal medicine
Respiratory Medicine/Respiratory Failure
medicine
Animals
Estrogen Receptor beta
Estrogen receptor beta
030304 developmental biology
Physiology/Endocrinology
lcsh:R
Estrogen Receptor alpha
030208 emergency & critical care medicine
Estrogens
medicine.disease
Rats
Endocrinology
Critical Care and Emergency Medicine/Renal and Gastrointestinal Critical Care
Enterocytes
Estrogen
Physiology/Cell Signaling
Surgery
lcsh:Q
Multiple organ dysfunction syndrome
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 5
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....f2566ba7421d3f4a87f6606f456947a7