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Resumption of Ovarian Function After Ovarian Biopsy/Scratch in Patients With Premature Ovarian Insufficiency
- Source :
- Reproductive sciences (Thousand Oaks, Calif.). 26(2)
- Publication Year :
- 2018
-
Abstract
- To evaluate the effect of ovarian biopsy and scratch on the resumption of ovarian function in women with premature ovarian insufficiency (POI), the follicle development and pregnancy outcome were retrospectively analyzed in women with POI after ovarian biopsy/scratch. Eighty patients with POI with secondary amenorrhea were accepted the laparoscopic surgery, and then hormone replacement treatment for 6 months was applied and in vitro fertilization and embryo transfer was suggested. No significant difference in clinical characteristics was observed before and after ovarian biopsy/scratch ( P > .05). After the ovarian surgery, 11 (13.75%) patients presented with ovarian function resumption spontaneously or with human menopausal gonadotropin stimulation. Three metaphases II oocytes were retrieved in 10 patients. Two embryos were formed and freshly transferred followed by a healthy singleton delivery in 1 (1.25%) patient. Patients with follicle development had higher baseline estradiol compared to those without (78.20 [18.53-161.08] pg/mL vs 15.70 [8.40-43.80] pg/mL, P < .01). The technique of ovarian biopsy/scratch could promote follicle development in vivo, suggesting it could bring promising benefits for some women with POI. However, future improvement in efficiency and practice criteria is warranted.
- Subjects :
- 0301 basic medicine
Laparoscopic surgery
Adult
endocrine system
medicine.medical_specialty
endocrine system diseases
medicine.medical_treatment
Biopsy
Reproductive medicine
Urology
Fertilization in Vitro
Primary Ovarian Insufficiency
Premature ovarian insufficiency
03 medical and health sciences
Follicle
0302 clinical medicine
Ovarian Follicle
In vivo
Pregnancy
medicine
Humans
Retrospective Studies
030219 obstetrics & reproductive medicine
In vitro fertilisation
business.industry
Ovary
Pregnancy Outcome
Obstetrics and Gynecology
medicine.disease
Embryo transfer
030104 developmental biology
Female
business
Subjects
Details
- ISSN :
- 19337205
- Volume :
- 26
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Reproductive sciences (Thousand Oaks, Calif.)
- Accession number :
- edsair.doi.dedup.....f24cf9ec489da59f2c2cff61624fe9dd