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Immunodietica: A data-driven approach to investigate interactions between diet and autoimmune disorders
- Source :
- Journal of Translational Autoimmunity, Journal of Translational Autoimmunity, Vol 1, Iss, Pp-(2019)
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- Autoimmunity is on the rise around the globe. Diet has been proposed as a risk factor for autoimmunity and shown to modulate the severity of several autoimmune disorders. Yet, the interaction between diet and autoimmunity in humans remains largely unstudied. Here, we systematically interrogated commonly consumed animals and plants for peptide epitopes previously implicated in human autoimmune disease. A total of fourteen species investigated could be divided into three broad categories regarding their content in human autoimmune epitopes, which we represented using a new metric, the Gershteyn-Ferreira index (GF index). Strikingly, pig contains a disproportionately high number of unique autoimmune epitopes compared to all other species analyzed. This work uncovers a potential new link between pork consumption and autoimmunity in humans and lays the foundation for future studies on the impact of diet on the pathogenesis and progression of autoimmune disorders.<br />Highlights • We developed a comprehensive database of dietary-human autoimmune epitope overlap. • The Gershteyn-Ferreira index divides dietary antigens into three main groups with respect to overlap with human autoimmune epitopes. • Pig contains a disproportionately high number of unique human autoimmune epitopes.
Details
- Database :
- OpenAIRE
- Journal :
- Journal of Translational Autoimmunity, Journal of Translational Autoimmunity, Vol 1, Iss, Pp-(2019)
- Accession number :
- edsair.doi.dedup.....f2493ee750a077901563f2294f5575d8