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Optical coherence tomography for glaucoma diagnosis: An evidence based meta-analysis
- Source :
- PLoS ONE, PLoS ONE, Vol 13, Iss 1, p e0190621 (2018)
- Publication Year :
- 2018
- Publisher :
- Public Library of Science, 2018.
-
Abstract
- Purpose Early detection, monitoring and understanding of changes in the retina are central to the diagnosis of glaucomatous optic neuropathy, and vital to reduce visual loss from this progressive condition. The main objective of this investigation was to compare glaucoma diagnostic accuracy of commercially available optical coherence tomography (OCT) devices (Zeiss Stratus, Zeiss Cirrus, Heidelberg Spectralis and Optovue RTVue, and Topcon 3D-OCT). Patients 16,104 glaucomatous and 11,543 normal eyes reported in 150 studies. Methods Between Jan. 2017 and Feb 2017, MEDLINE®, EMBASE®, CINAHL®, Cochrane Library®, Web of Science®, and BIOSIS® were searched for studies assessing glaucoma diagnostic accuracy of the aforementioned OCT devices. Meta-analysis was performed pooling area under the receiver operating characteristic curve (AUROC) estimates for all devices, stratified by OCT type (RNFL, macula), and area imaged. Results 150 studies with 16,104 glaucomatous and 11,543 normal control eyes were included. Key findings: AUROC of glaucoma diagnosis for RNFL average for all glaucoma patients was 0.897 (0.887-0.906, n = 16,782 patient eyes), for macula ganglion cell complex (GCC) was 0.885 (0.869-0.901, n = 4841 eyes), for macula ganglion cell inner plexiform layer (GCIPL) was 0.858 (0.835-0.880, n = 4211 eyes), and for total macular thickness was 0.795 (0.754-0.834, n = 1063 eyes). Conclusion The classification capability was similar across all 5 OCT devices. More diagnostically favorable AUROCs were demonstrated in patients with increased glaucoma severity. Diagnostic accuracy of RNFL and segmented macular regions (GCIPL, GCC) scans were similar and higher than total macular thickness. This study provides a synthesis of contemporary evidence with features of robust inclusion criteria and large sample size. These findings may provide guidance to clinicians when navigating this rapidly evolving diagnostic area characterized by numerous options.
- Subjects :
- Male
genetic structures
Eye Diseases
lcsh:Medicine
Glaucoma
Diagnostic Radiology
0302 clinical medicine
Mathematical and Statistical Techniques
Nerve Fibers
Animal Cells
Medicine and Health Sciences
Medicine
lcsh:Science
Tomography
Neurons
Multidisciplinary
medicine.diagnostic_test
Radiology and Imaging
Middle Aged
medicine.anatomical_structure
Meta-analysis
Physical Sciences
Female
Cellular Types
Anatomy
Statistics (Mathematics)
Tomography, Optical Coherence
Research Article
medicine.medical_specialty
Ganglion Cells
Cell complex
Imaging Techniques
Ocular Anatomy
Early detection
Research and Analysis Methods
Sensitivity and Specificity
Optic Disc
03 medical and health sciences
Optical coherence tomography
Diagnostic Medicine
Ocular System
Ophthalmology
Humans
In patient
Statistical Methods
Retina
Receiver operating characteristic
business.industry
lcsh:R
Biology and Life Sciences
Cell Biology
medicine.disease
eye diseases
Cellular Neuroscience
030221 ophthalmology & optometry
Eyes
lcsh:Q
sense organs
business
Head
030217 neurology & neurosurgery
Mathematics
Meta-Analysis
Neuroscience
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....f2455efe05c65a07ff3b8b7e469ba0b9