Back to Search
Start Over
Safety of intravenous nitroglycerin after administration of sildenafil citrate to men with coronary artery disease: a double-blind, placebo-controlled, randomized, crossover trial
- Source :
- Critical care medicine. 35(8)
- Publication Year :
- 2007
-
Abstract
- OBJECTIVE: Although contraindicated, there are situations when a patient who has recently taken a phosphodiesterase 5 inhibitor (e.g., sildenafil) might need intravenous nitroglycerin (NTG) treatment. This study determined if, and at what dose, intravenous NTG could be administered safely to men with coronary artery disease who had recently ingested sildenafil. DESIGN: Double-blind, placebo-controlled, randomized, crossover trial. SETTING: Four clinical practice sites in Canada, Scotland, and the United States. PATIENTS: A total of 34 men (>or=35 yrs) with a history of angina pectoris and coronary artery disease (>50% stenosis of at least one coronary artery), most of whom were taking antihypertensives. INTERVENTIONS: Sildenafil (100 mg) or placebo (single dose; crossover after 3-7 days) followed 45 mins later by escalating doses of intravenous NTG (160 microg/min maximum). MEASUREMENTS AND MAIN RESULTS: After sildenafil, there were slightly greater maximum (supine) blood pressure decreases and heart rate increases (e.g., 4 to 6 mm Hg [systolic] and
- Subjects :
- Male
medicine.drug_mechanism_of_action
Drug-Related Side Effects and Adverse Reactions
Sildenafil
Phosphodiesterase Inhibitors
Vasodilator Agents
Coronary Disease
Critical Care and Intensive Care Medicine
Placebo
Piperazines
Sildenafil Citrate
Angina
Coronary artery disease
chemistry.chemical_compound
Nitroglycerin
Double-Blind Method
Intensive care
Medicine
Humans
Drug Interactions
Sulfones
Infusions, Intravenous
Aged
Aged, 80 and over
Cross-Over Studies
Dose-Response Relationship, Drug
business.industry
Middle Aged
medicine.disease
Crossover study
Blood pressure
chemistry
Purines
Anesthesia
Blood Circulation
business
Phosphodiesterase 5 inhibitor
Subjects
Details
- ISSN :
- 00903493
- Volume :
- 35
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Critical care medicine
- Accession number :
- edsair.doi.dedup.....f243a0ee04695734347ee1c5df5fada9