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<scp>TGF</scp>‐β cascade regulation by<scp>PPP</scp>1 and its interactors –impact on prostate cancer development and therapy
- Source :
- Recercat. Dipósit de la Recerca de Catalunya, instname, Repositório Científico de Acesso Aberto de Portugal, Repositório Científico de Acesso Aberto de Portugal (RCAAP), instacron:RCAAP, Dipòsit Digital de la UB, Universidad de Barcelona, Journal of Cellular and Molecular Medicine
- Publication Year :
- 2014
- Publisher :
- Wiley, 2014.
-
Abstract
- Protein phosphorylation is a key mechanism by which normal and cancer cells regulate their main transduction pathways. Protein kinases and phosphatases are precisely orchestrated to achieve the (de)phosphorylation of candidate proteins. Indeed, cellular health is dependent on the fine-tune of phosphorylation systems, which when deregulated lead to cancer. Transforming growth factor beta (TGF-β) pathway involvement in the genesis of prostate cancer has long been established. Many of its members were shown to be hypo- or hyperphosphorylated during the process of malignancy. A major phosphatase that is responsible for the vast majority of the serine/threonine dephosphorylation is the phosphoprotein phosphatase 1 (PPP1). PPP1 has been associated with the dephosphorylation of several proteins involved in the TGF-β cascade. This review will discuss the role of PPP1 in the regulation of several TGF-β signalling members and how the subversion of this pathway is related to prostate cancer development. Furthermore, current challenges on the protein phosphatases field as new targets to cancer therapy will be addressed. published
- Subjects :
- Male
TGF-β
Cellular signal transduction
Carcinogenesis
Review
Biology
phosphatase
Dephosphorylation
Fosforilació
Prostate cancer
Transforming Growth Factor beta
Protein Phosphatase 1
Phosphatase
medicine
Humans
Protein phosphorylation
Phosphorylation
Proteïnes supressores de tumors
PPP1
Càncer de pròstata
Kinase
Phosphatases
Prostatic Neoplasms
Transducció de senyal cel·lular
Protein phosphatase 1
PIP
Cell Biology
Transforming growth factor beta
prostate cancer
medicine.disease
signal transduction therapy
Fosfatases
Tumor suppressor protein
Extracellular Matrix
Signal transduction therapy
3. Good health
Growth Differentiation Factors
Biochemistry
Cancer research
biology.protein
Molecular Medicine
Signal transduction
Signal Transduction
Subjects
Details
- ISSN :
- 15824934 and 15821838
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Journal of Cellular and Molecular Medicine
- Accession number :
- edsair.doi.dedup.....f23ebd1457dc8b729bd33edc42ec411f