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Antiproliferative Effect of Somatostatin and Analogs
- Source :
- Chemotherapy. 47:30-39
- Publication Year :
- 2001
- Publisher :
- S. Karger AG, 2001.
-
Abstract
- Over the past decade, antiproliferative effects of somatostatin and analogs have been reported in many somatostatin receptor-positive normal and tumor cell types. Regarding the molecular mechanisms involved, somatostatin or analogs mediate their action through both indirect and direct effects. Somatostatin acts through five somatostatin receptors (SSTR1–5) which are variably expressed in normal and tumor cells. These receptors regulate a variety of signal transduction pathways including inhibition of adenylate cyclase, regulation of ion channels, regulation of serine/threonine and tyrosine kinases and phosphatases. This review focuses on recent advances in biological mechanisms involved in the antineoplastic activity of somatostatin and analogs.
- Subjects :
- endocrine system
Antineoplastic Agents, Hormonal
Neuropeptide
Neoplasms
Drug Discovery
medicine
Animals
Humans
Pharmacology (medical)
Receptors, Somatostatin
Receptor
Pharmacology
Somatostatin receptor
Chemistry
Cell growth
General Medicine
Infectious Diseases
Somatostatin
Oncology
Biochemistry
Mechanism of action
Cancer research
medicine.symptom
Signal transduction
Tyrosine kinase
Cell Division
hormones, hormone substitutes, and hormone antagonists
Signal Transduction
Subjects
Details
- ISSN :
- 14219794 and 00093157
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Chemotherapy
- Accession number :
- edsair.doi.dedup.....f23546fe1e71fc5d8ee853c465633ffd