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Medication adherence and persistence of psoriatic arthritis patients treated with biological therapy in a specialty pharmacy in Brazil: a prospective observational study
- Source :
- Pharmacy Practice, Vol 19, Iss 2, p 2312 (2021), Pharmacy Practice, Pharmacy Practice (Granada) v.19 n.2 2021, SciELO España: Revistas Científicas Españolas de Ciencias de la Salud, Instituto de Salud Carlos III (ISCIII), SciELO España. Revistas Científicas Españolas de Ciencias de la Salud, instname
- Publication Year :
- 2021
- Publisher :
- Centro de Investigaciones y Publicaciones Farmaceuticas, 2021.
-
Abstract
- Background : Pharmaceutical services in Brazil provide access, supply, and rational use of drugs for all population and an effort has been made to improve the quality of these services. Biological drugs are high - cost drugs supplied in Brazil t hat can inhibit disease progression and improve the quality of life of psoriatic arthritis (PsA) patients. However, some patients did not achieve the rapeutic goals. Objective : T o evaluate the medication adherence and persistence of PsA patients treated with tumor necrosis factor inhibitors (anti - TNF) drugs and their associated factors. Methods : A prospective observational study was performed at a single - specialty pharmacy in Belo Horizonte, Brazil. Medication adherenc e, persistence, and clinical outcomes were evaluated at 12 months of follow - up. Medication persistence was historically compared to overall PsA patients treated in Brazil. Associated factors were identified through log - binomial regression. Results : One hu ndred ninety - seven PsA patients were included in the study, of whom 147 (74.6%) and 142 (72.1%) had medication adherence and persistence, respectively. Patients treated with infliximab presented the highest adherence (90.5%) and persist ence rate (95.2%) in comparison to patients treated with other drugs, except for adalimumab versus infliximab for adherence outcome. All clinical measures significantly improved in patients with medication adherence and persistence. Medication persistence was hi gher for patie nts attended by specialty pharmacy than other PsA patients in Brazil. The associated factors to higher medication adherence w ere lower disease activity by BASDAI, being non - white race, and intravenous drug use. The associated factors to higher medication p ersistence were lower disease activity by Bath Ankylosing Spondylitis Activity Index (BASDAI), intravenous drug use, non - use of corticoids and non - steroidal anti - inflammatory drugs, and comorbidity. Conclusions : Patients with medication adherence and pers istence had significant improvements in clinical measures, functionality, and quality of life. High medication adherence and persistence to biological therapy were observed and associated with lesser dis ease activity at baseline. Also, medication persisten ce to PsA patients attended in specialty pharmacy was higher than the overall PsA population in Brazil, which indicates the importance of pharmaceutical services to provide health care and promote the effect iveness and safety of biological therapies.
- Subjects :
- mesh:Arthritis, Psoriatic
mesh:Etanercept
tumor necrosis factor inhibitors
pharmacists
Pharmaceutical Science
mesh:Disease Progression
Pharmacy
Pharmacists
Etanercept
mesh:Quality of Life
mesh:Brazil
adalimumab
Prospective Studies
mesh:Infliximab
BASDAI
Original Research
education.field_of_study
mesh:Medication Adherence
follow-up studies
Biological Therapy
mesh:Biological Therapy
brazil
biological therapy
Disease Progression
Goals
Brazil
mesh:Prospective Studies
medicine.drug
mesh:Tumor Necrosis Factor Inhibitors
medicine.medical_specialty
Population
RM1-950
patient outcome assessment
Medication Adherence
disease progression
pharmacies
pharmaceutical services
Pharmacy and materia medica
Internal medicine
arthritis psoriatic
medicine
Adalimumab
mesh:Goals
mesh:Pharmacists
goals
education
Pharmacies
mesh:Adalimumab
business.industry
Arthritis, Psoriatic
mesh:Pharmacies
mesh:Follow-Up Studies
Infliximab
prospective studies
Patient Outcome Assessment
RS1-441
mesh:Pharmaceutical Services
quality of life
mesh:Patient Outcome Assessment
Pharmaceutical Services
Medication Persistence
Specialty pharmacy
medication adherence
Quality of Life
Tumor Necrosis Factor Inhibitors
Therapeutics. Pharmacology
business
infliximab
etanercept
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 18863655
- Volume :
- 19
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Pharmacy Practice
- Accession number :
- edsair.doi.dedup.....f22454d5ad5977b71cc9d57b43adad48