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CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines
- Source :
- Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-9 (2019), Arthritis Research & Therapy
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Background Recent studies show that innate lymphoid cells (ILCs) contribute to the development of chronic inflammation and autoimmune disease. In this study, we assessed the ILC function in the development of rheumatoid arthritis (RA). Methods In a mouse model of collagen-induced arthritis (CIA), we identified and purified the ILC subsets in peripheral blood (PB), local lymph nodes (LNs), and joints by fluorescence-activated cell sorting and used quantitative PCR to assess the expression levels of representative cytokines. We also correlated the frequencies of each ILC subset in synovial fluid (SF) with clinical parameters in RA patients. Results In the CIA model, the proportion of CCR6+ ILC3s to total ILCs in joints with active inflammation significantly increased relative to non-arthritic joints (median 29.6% vs 16.7%, p = 0.035). CCR6+ ILC3s from mice with arthritis expressed significantly higher levels of IL-17A and IL-22 mRNA than did comparable cells from control mice (p
- Subjects :
- Male
Receptors, CCR6
0301 basic medicine
medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Arthritis
Innate lymphoid cells
Inflammation
C-C chemokine receptor type 6
Th17 cytokines
Arthritis, Rheumatoid
Mice
03 medical and health sciences
0302 clinical medicine
Internal medicine
Synovial Fluid
Animals
Humans
Medicine
Synovial fluid
Rheumatoid arthritis
skin and connective tissue diseases
030203 arthritis & rheumatology
business.industry
Interleukin-17
Innate lymphoid cell
medicine.disease
Immunity, Innate
Rheumatology
Mice, Inbred C57BL
CCL20
Disease Models, Animal
030104 developmental biology
Gene Expression Regulation
Immunology
Disease Progression
RNA
Th17 Cells
lcsh:RC925-935
medicine.symptom
CCR6
business
Research Article
Subjects
Details
- ISSN :
- 14786362
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Arthritis Research & Therapy
- Accession number :
- edsair.doi.dedup.....f211da202cfa3d37411e0ea75a29802f