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Pandemic H1N1 vaccine requires the use of an adjuvant to protect against challenge in naive ferrets
- Source :
- Vaccine, 29(11), 2120-2126. Elsevier
- Publication Year :
- 2011
-
Abstract
- In the context of an A/H1N1 influenza pandemic situation, this study demonstrates that heterologous vaccination with an AS03-adjuvanted 2008/2009 seasonal trivalent and pandemic H5N1 monovalent split vaccine conferred partial protection in influenza-naive ferrets after challenge with the influenza pandemic H1N1 A/The Netherlands/602/09 virus. Further, unlike saline control and non-adjuvanted vaccine, it was shown that immunization of naive ferrets with an AS03-adjuvanted pandemic H1N1 A/California/7/09 influenza split vaccine induced increased antibody response and enhanced protection against the challenge strain, including significant reduction in viral shedding in the upper respiratory tract and reduced lung pathology post-challenge. These results show the need for vaccination with the adjuvanted vaccine to fully protect against viral replication and influenza disease in unprimed ferrets. (C) 2011 Elsevier Ltd. All rights reserved.
- Subjects :
- Influenza vaccine
Biology
medicine.disease_cause
Antibodies, Viral
Virus Replication
Influenza A Virus, H1N1 Subtype
Adjuvants, Immunologic
Orthomyxoviridae Infections
SDG 3 - Good Health and Well-being
Neutralization Tests
Pandemic
Influenza A virus
medicine
Live attenuated influenza vaccine
Animals
AS03
Viral shedding
Lung
General Veterinary
General Immunology and Microbiology
Influenza A Virus, H5N1 Subtype
Public Health, Environmental and Occupational Health
Ferrets
virus diseases
Viral Load
Virology
Influenza A virus subtype H5N1
Virus Shedding
Vaccination
Infectious Diseases
Influenza Vaccines
Immunology
Molecular Medicine
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 29
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....f20d3cb10a51abec7ac10f0212032454