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Genetic aetiology of self-harm ideation and behaviour
- Source :
- Scientific Reports, 10, Scientific Reports, Scientific Reports, 10(1):9713. Nature Publishing Group, Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Campos, A I, Verweij, K J H, Statham, D J, Madden, P A F, Maciejewski, D F, Davis, K A S, John, A, Hotopf, M, Heath, A C, Martin, N G & Rentería, M E 2020, ' Genetic aetiology of self-harm ideation and behaviour ', Scientific Reports, vol. 10, no. 1, 9713 . https://doi.org/10.1038/s41598-020-66737-9, Scientific reports, 10(1):9713. Nature Publishing Group
- Publication Year :
- 2020
-
Abstract
- Family studies have identified a heritable component to self-harm that is partially independent from comorbid psychiatric disorders. However, the genetic aetiology of broad sense (non-suicidal and suicidal) self-harm has not been characterised on the molecular level. In addition, controversy exists about the degree to which suicidal and non-suicidal self-harm share a common genetic aetiology. In the present study, we conduct genome-wide association studies (GWAS) on lifetime self-harm ideation and self-harm behaviour (i.e. any lifetime self-harm act regardless of suicidal intent) using data from the UK Biobank (n > 156,000). We also perform genome wide gene-based tests and characterize the SNP heritability and genetic correlations between these traits. Finally, we test whether polygenic risk scores (PRS) for self-harm ideation and self-harm behaviour predict suicide attempt, suicide thoughts and non-suicidal self-harm (NSSH) in an independent target sample of 8,703 Australian adults. Our GWAS results identified one genome-wide significant locus associated with each of the two phenotypes. SNP heritability (hsnp2) estimates were ~10%, and both traits were highly genetically correlated (LDSC rg > 0.8). Gene-based tests identified seven genes associated with self-harm ideation and four with self-harm behaviour. Furthermore, in the target sample, PRS for self-harm ideation were significantly associated with suicide thoughts and NSSH, and PRS for self-harm behaviour predicted suicide thoughts and suicide attempt. Follow up regressions identified a shared genetic aetiology between NSSH and suicide thoughts, and between suicide thoughts and suicide attempt. Evidence for shared genetic aetiology between NSSH and suicide attempt was not statistically significant.
- Subjects :
- 0301 basic medicine
Adult
Male
Multifactorial Inheritance
lcsh:Medicine
Genome-wide association study
Locus (genetics)
Suicide, Attempted
Polymorphism, Single Nucleotide
Article
Suicidal Ideation
03 medical and health sciences
0302 clinical medicine
Risk Factors
Databases, Genetic
medicine
SNP
Humans
lcsh:Science
Suicidal ideation
Genetic association
Emotion
Multidisciplinary
Suicide attempt
lcsh:R
Australia
Heritability
Middle Aged
Biobank
030104 developmental biology
Behavioural genetics
lcsh:Q
Female
medicine.symptom
Psychology
Self-Injurious Behavior
Developmental Psychopathology
030217 neurology & neurosurgery
Clinical psychology
Genome-Wide Association Study
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Database :
- OpenAIRE
- Journal :
- Scientific Reports, 10, Scientific Reports, Scientific Reports, 10(1):9713. Nature Publishing Group, Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020), Campos, A I, Verweij, K J H, Statham, D J, Madden, P A F, Maciejewski, D F, Davis, K A S, John, A, Hotopf, M, Heath, A C, Martin, N G & Rentería, M E 2020, ' Genetic aetiology of self-harm ideation and behaviour ', Scientific Reports, vol. 10, no. 1, 9713 . https://doi.org/10.1038/s41598-020-66737-9, Scientific reports, 10(1):9713. Nature Publishing Group
- Accession number :
- edsair.doi.dedup.....f202c1df102352bb356c9a566b0c4e3e