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Sickness Behavior Score Is Associated with Neuroinflammation and Late Behavioral Changes in Polymicrobial Sepsis Animal Model
- Source :
- Inflammation. 43(3)
- Publication Year :
- 2020
-
Abstract
- The use of reliable scores is a constant development in critical illness. According to Sepsis-3 consensus, the use of Sequential Organ Failure Assessment (SOFA) score of 2 or more is associated with a higher mortality of sepsis patients. In experimental research, due murine animal model limitations, the use of a score systems can be an alternative to assess sepsis severity. In this work, we suggest a sickness behavior score (SBS) that uses physiological variables to assess sepsis severity and mortality. Animals were evaluated daily by the presence of six indicators of sickness behavior: temperature alteration, preference of water/sucrose, liquid intake, food intake, body weight, and movimentation. Male adult Wistar rats were evaluated daily after sepsis induction by cecal ligation and puncture (CLP) or laparotomy only (sham) for determination of SBS. Oxidative stress, IL-6, and HPA axis markers (corticosterone and adrenal gland weight) were evaluated 24 h after CLP to determine the correlation with the acute SBS and neuroinflammation. Also, BDNF and four cognitive behavioral tests were correlated with the chronic SBS, i.e., sum of 8 days after surgery. In result, septic rats presented higher SBS than sham animals. Sepsis severity markers were associated with acute and chronic SBS. Also, SBS was negative correlated with the cognitive tests. In conclusion, SBS shows to be reliable score to predict sepsis severity and mortality. The use of score system provides the analysis of global sickness behavior, beyond evaluation of each parameter individually.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
medicine.medical_treatment
Immunology
medicine.disease_cause
Gastroenterology
Sepsis
03 medical and health sciences
chemistry.chemical_compound
Eating
0302 clinical medicine
Corticosterone
Laparotomy
Internal medicine
medicine
Immunology and Allergy
Animals
Rats, Wistar
Sickness behavior
Depression (differential diagnoses)
Illness Behavior
Inflammation
business.industry
Coinfection
medicine.disease
Rheumatology
Cognitive test
Rats
Disease Models, Animal
Oxidative Stress
030104 developmental biology
chemistry
030220 oncology & carcinogenesis
Inflammation Mediators
business
Oxidative stress
Locomotion
Subjects
Details
- ISSN :
- 15732576
- Volume :
- 43
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Inflammation
- Accession number :
- edsair.doi.dedup.....f1c23ac885cd5f7d44d015805734b813