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Cutaneous neuroimmune crosstalk in pruritus
- Source :
- Trends in Molecular Medicine. 28:452-462
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- The underlying mechanisms of chronic pruritus (CP), which is often very debilitating for patients, are still not well understood. Over the past few years, peripheral and central mechanisms involving different classes of pruriceptive and nociceptive neuron (e.g., C- and Aδ-fibers), immune cells (e.g., eosinophils, basophils, Th1, Th2, and mast cells) and epithelial cells (e.g., keratinocytes) have been investigated. Based on these, numerous promising target-specific therapies are under development. In this review, we highlight the cells, key mediators, and receptors involved in itch perception and CP, and conclude by summarizing the therapies developed for these conditions.
- Subjects :
- Keratinocytes
Pruritus
Humans
Molecular Medicine
Molecular Biology
Basophils
Skin
Subjects
Details
- ISSN :
- 14714914
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Trends in Molecular Medicine
- Accession number :
- edsair.doi.dedup.....f1b2bc6fbfcc0a44c0ba744d91a97db2