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Nail apparatus melanoma in a Japanese population: a comparative study of surgical procedures and prognoses in a large series of 151 cases
- Source :
- European Journal of Dermatology. 27:620-626
- Publication Year :
- 2017
- Publisher :
- John Libbey Eurotext, 2017.
-
Abstract
- Nail apparatus melanoma (NAM) is a rare subtype of malignant melanoma with a prevalence that varies among populations. Conservative surgical approaches for thin to intermediate NAMs have recently been reported, however, their adoption is controversial, and resulting long-term prognoses are unknown. The purpose of this study was to determine the prognosis of NAM in a sample Asian population, and to investigate whether there is a difference in the local control and overall survival (OS) rates according to the extent of resection of the primary tumour. We performed a retrospective study of NAM patients treated at five medical institutions in Japan between 2000 and 2013. Outcomes according to surgery (amputation vs. resection) and tumour thickness were compared. We identified 151 cases of NAM in 83 men and 68 women; the thumb (n = 50; 33.1%) and hallux (n = 55; 36.4%) were the most common sites. No local recurrence was detected following any of the surgical procedures; Kaplan-Meier survival analysis revealed that the surgical procedure type was not significantly associated with disease-free survival (p = 0.786) or OS (p = 0.997). Five-year OS rates according to tumour thickness were 100% for in situ, 94.4% for ≤1-mm, 91.7% for 1.01-2.0-mm, 72.7% for 2.01-4.0-mm, and 47.6% for ≥4.01-mm tumours. Surgical procedure type does not influence survival as long as total primary tumour resection is accomplished. The prognosis of NAM is comparable to that of other types of melanoma.
- Subjects :
- Adult
Male
medicine.medical_specialty
Skin Neoplasms
medicine.medical_treatment
Dermatology
Nail Diseases
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
Japan
medicine
Overall survival
Humans
Melanoma
Survival analysis
Nail Apparatus
Aged
Retrospective Studies
Aged, 80 and over
business.industry
Retrospective cohort study
Middle Aged
Surgical procedures
Prognosis
medicine.disease
Surgery
Amputation
Nail disease
030220 oncology & carcinogenesis
Female
business
Subjects
Details
- ISSN :
- 19524013 and 11671122
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- European Journal of Dermatology
- Accession number :
- edsair.doi.dedup.....f1abf68389ab2425455110c810d8371f