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Atherosclerosis: Recent trials, new targets and future directions
- Source :
- International Journal of Cardiology, International Journal of Cardiology, 2015, 192, pp.72-81. ⟨10.1016/j.ijcard.2015.05.013⟩, International Journal of Cardiology, Elsevier, 2015, 192, pp.72-81. ⟨10.1016/j.ijcard.2015.05.013⟩
- Publication Year :
- 2015
- Publisher :
- HAL CCSD, 2015.
-
Abstract
- International audience; Mortality from cardiovascular diseases (CVD) represents the primary cause of death worldwide. Prevention or treatment of atherosclerosis and its clinical sequelae is a central goal in the management of patients with established vascular disease or those at high-risk for vascular events. This paper provides a review of the contemporary pharmacological armamentarium targeting atherosclerosis and also highlights strategies to support future clinical trial design. Powering future trials targeting LDL-cholesterol to its absolute reduction and including patients with a higher LDL-C despite optimal medical therapy (or unable to tolerate statins) will increase the odds of meaningful results. Mendelian randomization studies may identify new causal risk factors for CVD that would help in the selection of the patients most likely to benefit from a specific new compound. Furthermore, imaging techniques integrating a morphological and functional assessment such as IVUS, OCT, PET/CT and PET/MRI may represent in a near future robust "soft" endpoints to support successful translation of early research into meaningful phase III clinical outcome trials.
- Subjects :
- medicine.medical_specialty
Pathology
MESH: Clinical Trials as Topic
Clinical research
MESH: Atherosclerosis
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Mendelian randomization
MESH: Molecular Targeted Therapy
Humans
Medicine
Molecular Targeted Therapy
Intensive care medicine
Cause of death
Pharmacology
Clinical Trials as Topic
MESH: Humans
business.industry
Vascular disease
Clinical study design
medicine.disease
Atherosclerosis
3. Good health
Cardiology and Cardiovascular Medicine
business
Medical therapy
Subjects
Details
- Language :
- English
- ISSN :
- 01675273 and 18741754
- Database :
- OpenAIRE
- Journal :
- International Journal of Cardiology, International Journal of Cardiology, 2015, 192, pp.72-81. ⟨10.1016/j.ijcard.2015.05.013⟩, International Journal of Cardiology, Elsevier, 2015, 192, pp.72-81. ⟨10.1016/j.ijcard.2015.05.013⟩
- Accession number :
- edsair.doi.dedup.....f1a5d9b73d286f72b6f6c65a54c9b6c9