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Evolutionary origin of human and simian immunodeficiency viruses
- Source :
- Proceedings of the National Academy of Sciences. 87:4108-4111
- Publication Year :
- 1990
- Publisher :
- Proceedings of the National Academy of Sciences, 1990.
-
Abstract
- From what viruses the human immunodeficiency viruses (HIVs) originated is an extremely controversial question. To address this question, we have analyzed nucleotide sequences of simian immunodeficiency viruses (SIVs) and HIVs by using the techniques for understanding molecular evolution. In particular, we compared the nucleotide sequences of whole genomes, gene region by gene region, between a given pair of viruses, including four types of SIVs--isolated from mandrills (Papio sphinx), African green monkeys (Cercopithecus aethiops), sooty mangabeys (Cercocebus atys), and rhesus macaques (Macaca mulatta)--as well as HIVs. Phylogenetic trees for all gene regions examined showed that the present HIVs may have emerged as different variants of SIVs of Old World monkeys, possibly from recombination between viruses related to SIVs.
- Subjects :
- Genes, Viral
animal diseases
viruses
Retroviridae Proteins
Simian
medicine.disease_cause
Cercopithecus aethiops
Virus
Molecular evolution
Phylogenetics
medicine
Gene
Phylogeny
Viral Structural Proteins
Genetics
Multidisciplinary
biology
Phylogenetic tree
HIV
virus diseases
RNA-Directed DNA Polymerase
Simian immunodeficiency virus
Endonucleases
biology.organism_classification
Biological Evolution
Virology
Retroviridae
Simian Immunodeficiency Virus
Research Article
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....f19f0d5037dcba205143dc47a6488fdd