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α1-adrenergic regulation of thyrotropin-stimulated release of 3, 5, 3’ -triiodothyronine and thyroxine from perifused mouse thyroid
- Source :
- Journal of Endocrinological Investigation. 14:867-873
- Publication Year :
- 1991
- Publisher :
- Springer Science and Business Media LLC, 1991.
-
Abstract
- The effect of methoxamine, a specific alpha 1-adrenergic agonist, on the release of T3, T4 and cAMP from perifused mouse thyroid was studied to clarify the role of the alpha 1-adrenergic receptor in the regulation of thyroid hormone secretion. TSH-stimulated T3 and T4 release was inhibited significantly by methoxamine. With regard to cAMP release, methoxamine inhibited TSH-stimulated cAMP release in the presence of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone but did not inhibit TSH-stimulated cAMP release in the presence of 3-isobutyl-1-methylxanthine. Methoxamine did significantly suppress TSH-stimulated release of T3 and T4 in the presence of each phosphodiesterase inhibitor. Depletion of Ca2+ in the perifusion buffer abolished completely the inhibitory effect of methoxamine on TSH-stimulated T3 and T4 release. The present study suggests that activation of the alpha 1-adrenergic receptor inhibits TSH-stimulated T3 and T4 secretion through a Ca(2+)-dependent mechanism in the mouse thyroid gland.
- Subjects :
- Male
Agonist
endocrine system
medicine.medical_specialty
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
endocrine system diseases
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Thyroid Gland
Thyrotropin
Adrenergic
Biology
Methoxamine
Mice
Endocrinology
1-Methyl-3-isobutylxanthine
Internal medicine
Cyclic AMP
medicine
Prazosin
Animals
Phosphodiesterase inhibitor
Receptor
Triiodothyronine
Dose-Response Relationship, Drug
Thyroid
Receptors, Adrenergic, alpha
Thyroxine
medicine.anatomical_structure
Calcium
hormones, hormone substitutes, and hormone antagonists
medicine.drug
Subjects
Details
- ISSN :
- 17208386 and 03914097
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Endocrinological Investigation
- Accession number :
- edsair.doi.dedup.....f18c49e13a628379f48c0703cd48005c