Back to Search
Start Over
SOS2 and ACP1 loci identified through large-scale exome chip analysis regulate kidney development and function
- Source :
- J. Am. Soc. Nephrol. 28, 981-994 (2017), Journal of the American Society of Nephrology, 28(3), 981-994, Li, M, Li, Y, Weeks, O, Mijatovic, V, Teumer, A, Huffman, J E, Tromp, G, Fuchsberger, C, Gorski, M, Lyytikäinen, L-P, Nutile, T, Sedaghat, S, Sorice, R, Tin, A, Yang, Q, Ahluwalia, T S, Arking, D E, Bihlmeyer, N A, Böger, C A, Carroll, R J, Chasman, D I, Cornelis, M C, Dehghan, A, Faul, J D, Feitosa, M F, Gambaro, G, Gasparini, P, Giulianini, F, Heid, I, Huang, J, Imboden, M, Jackson, A U, Jeff, J, Jhun, M A, Katz, R, Kifley, A, Kilpeläinen, T O, Kumar, A, Laakso, M, Li-Gao, R, Lohman, K, Grarup, N, Hansen, T, Jørgensen, T, Jørgensen, M E, Lauritzen, T, Pedersen, O, Schmidt, F, Wang, J J, Witte, D & CHARGE Glycemic-T2D Working Group, 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology, vol. 28, no. 3, pp. 981-994 . https://doi.org/10.1681/ASN.2016020131, CHARGE Glycemic-T2D Working Group, & CHARGE Blood Pressure Working Group 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology, vol. 28, no. 3, pp. 981-994 . https://doi.org/10.1681/ASN.2016020131, Journal of the American Society of Nephrology, Journal of the American Society of Nephrology 28 (2017): 981–994. doi:10.1681/ASN.2016020131, info:cnr-pdr/source/autori:Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E.; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikainen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S.; Arking, Dan E.; Bihlmeyer, Nathan A.; Boeger, Carsten A.; Carroll, Robert J.; Chasman, Daniel I.; Comelis, Marilyn C.; Dehghan, Abbas; Faul, Jessica D.; Feitosa, Mary F.; Gambaro, Giovanni; Gasparini, Paolo; Giulianini, Franco; Heid, Iris; Huang, Jinyan; Imboden, Medea; Jackson, Anne U.; Jeff, Janina; Jhun, Min A.; Katz, Ronit; Kifley, Annette; Kilpelainen, Tuomas; Kumar, Ashish; Laakso, Markku; Li-Gao, Ruifang; Lohman, Kurt; Lu, Yingchang; Maegi, Reedik; Malerba, Giovanni; Mihailov, Evelin; Mohlke, Karen L.; Mook-Kanamori, Dennis O.; Robino, Antonietta; Ruderfer, Douglas; Salvi, Erika; Schick, Ursula M.; Schulz, Christina-Alexandra; Smith, Albert V.; Smith, Jennifer A.; Traglia, Michela; Yerges-Armstrong, Laura M.; Zhao, Wei; Goodarzi, Mark O.; Kraja, Aldi T.; Liu, Chunyu; Wessel, Jennifer; Boerwinkle, Eric; Borecki, Ingrid B.; Bork-Jensen, Jette; Bottinger, Erwin P.; Braga, Daniele; Brandslund, Ivan; Brody, Jennifer A.; Campbell, Archie; Carey, David J.; Christensen, Cramer; Coresh, Josef; Crook, Errol; Curhan, Gary C.; Cusi, Daniele; de Boer, Ian H.; de Vries, Aiko P. J.; Denny, Joshua C.; Devuyst, Olivier; Dreisbach, Albert W.; Endlich, Karlhans; Esko, Tonu; Franco, Oscar H.; Fulop, Tibor; Gerhard, Glenn S.; Gluemer, Charlotte; Gottesman, Omri; Grarup, Niels; Gudnason, Vilmundur; Hansen, Torben; Harris, Tamara B.; Hayward, Caroline; Hocking, Lynne; Hofman, Albert; Hu, Frank B.; Husemoen, Lise Lotte N.; Jackson, Rebecca D.; Jorgensen, Torben; Jorgensen, Marit E.; Kaehoenen, Mika; Kardia, Sharon L. R.; Koenig, Wolfgang; Kooperberg, Charles; Kriebel, Jennifer; Launer, Lenore J.; Lauritzen, Torsten; Lehtimaki, Terho; Levy, Daniel; Linksted, Pamela; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J. F.; Lupo, Antonio; Meisinger, Christine; Melander, Olle; Metspalu, Andres; Mitchell, Paul; Nauck, Matthias; Nuernberg, Peter; Orho-Melander, Marju; Parsa, Afshin; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Porteous, David; Probst-Hensch, Nicole M.; Psaty, Bruce M.; Qi, Lu; Raitakari, Olli T.; Reiner, Alex P.; Rettig, Rainer; Ridker, Paul M.; Rivadeneira, Fernando; Rossouw, Jacques E.; Schmidt, Frank; Siscovick, David; Soranzo, Nicole; Strauch, Konstantin; Toniolo, Daniela; Turner, Stephen T.; Uitterlinden, Andre G.; Ulivi, Sheila; Velayutham, Dinesh; Voelker, Uwe; Volzke, Henry; Waldenberger, Melanie; Wang, Jie Jin; Weir, David R.; Witte, Daniel; Kuivaniemi, Helena; Fox, Caroline S.; Franceschini, Nora; Goessling, Wolfram; Koettgen, Anna; Chu, Audrey Y./titolo:SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function/doi:10.1681%2FASN.2016020131/rivista:Journal of the American Society of Nephrology/anno:2017/pagina_da:981/pagina_a:994/intervallo_pagine:981–994/volume:28, Li, M, Li, Y, Weeks, O, Mijatovic, V, Teumer, A, Huffman, J E, Tromp, G, Fuchsberger, C, Gorski, M, Lyytikäinen, L-P, Nutile, T, Sedaghat, S, Sorice, R, Tin, A, Yang, Q, Ahluwalia, T S, Arking, D E, Bihlmeyer, N A, Böger, C A, Carroll, R J, Chasman, D I, Cornelis, M C, Dehghan, A, Faul, J D, Feitosa, M F, Gambaro, G, Gasparini, P, Giulianini, F, Heid, I, Huang, J, Imboden, M, Jackson, A U, Jeff, J, Jhun, M A, Katz, R, Kifley, A, Kilpeläinen, T O, Kumar, A, Laakso, M, Li-Gao, R, Lohman, K, Lu, Y, Mägi, R, Malerba, G, Mihailov, E, Mohlke, K L, Campbell, A, Hayward, C & Polasek, O & Porteous, D 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology . https://doi.org/10.1681/ASN.2016020131, Journal of the American Society of Nephrology, 28(3), 981-994. American Society of Nephrology
- Publication Year :
- 2017
- Publisher :
- Amer Soc Nephrology, 2017.
-
Abstract
- Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (nStage1: 111,666; nStage2: 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; PStage1
- Subjects :
- 0301 basic medicine
Nonsynonymous substitution
Nephrology
medicine.medical_specialty
human genetics
Renal function
Genome-wide association study
Single-nucleotide polymorphism
Biology
Kidney
03 medical and health sciences
0302 clinical medicine
kidney development
renal function
Clinical Research
Proto-Oncogene Proteins
Internal medicine
Animals
Exome
Genetic Loci
Genome-Wide Association Study
Glomerular Filtration Rate
Humans
Protein Tyrosine Phosphatases
Son of Sevenless Proteins
Zebrafish
Journal Article
medicine
Settore MED/14 - NEFROLOGIA
human genetic
Gene
Genetic association
Genetics
Proto-Oncogene Protein
Animal
Son of Sevenless Protein
General Medicine
ta3121
030104 developmental biology
Human Genetics
Kidney Development
Renal Function
Protein Tyrosine Phosphatase
genome, nephron
030217 neurology & neurosurgery
Meta-Analysis
Human
Subjects
Details
- Language :
- German
- ISSN :
- 10466673
- Database :
- OpenAIRE
- Journal :
- J. Am. Soc. Nephrol. 28, 981-994 (2017), Journal of the American Society of Nephrology, 28(3), 981-994, Li, M, Li, Y, Weeks, O, Mijatovic, V, Teumer, A, Huffman, J E, Tromp, G, Fuchsberger, C, Gorski, M, Lyytikäinen, L-P, Nutile, T, Sedaghat, S, Sorice, R, Tin, A, Yang, Q, Ahluwalia, T S, Arking, D E, Bihlmeyer, N A, Böger, C A, Carroll, R J, Chasman, D I, Cornelis, M C, Dehghan, A, Faul, J D, Feitosa, M F, Gambaro, G, Gasparini, P, Giulianini, F, Heid, I, Huang, J, Imboden, M, Jackson, A U, Jeff, J, Jhun, M A, Katz, R, Kifley, A, Kilpeläinen, T O, Kumar, A, Laakso, M, Li-Gao, R, Lohman, K, Grarup, N, Hansen, T, Jørgensen, T, Jørgensen, M E, Lauritzen, T, Pedersen, O, Schmidt, F, Wang, J J, Witte, D & CHARGE Glycemic-T2D Working Group, 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology, vol. 28, no. 3, pp. 981-994 . https://doi.org/10.1681/ASN.2016020131, CHARGE Glycemic-T2D Working Group, & CHARGE Blood Pressure Working Group 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology, vol. 28, no. 3, pp. 981-994 . https://doi.org/10.1681/ASN.2016020131, Journal of the American Society of Nephrology, Journal of the American Society of Nephrology 28 (2017): 981–994. doi:10.1681/ASN.2016020131, info:cnr-pdr/source/autori:Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E.; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikainen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S.; Arking, Dan E.; Bihlmeyer, Nathan A.; Boeger, Carsten A.; Carroll, Robert J.; Chasman, Daniel I.; Comelis, Marilyn C.; Dehghan, Abbas; Faul, Jessica D.; Feitosa, Mary F.; Gambaro, Giovanni; Gasparini, Paolo; Giulianini, Franco; Heid, Iris; Huang, Jinyan; Imboden, Medea; Jackson, Anne U.; Jeff, Janina; Jhun, Min A.; Katz, Ronit; Kifley, Annette; Kilpelainen, Tuomas; Kumar, Ashish; Laakso, Markku; Li-Gao, Ruifang; Lohman, Kurt; Lu, Yingchang; Maegi, Reedik; Malerba, Giovanni; Mihailov, Evelin; Mohlke, Karen L.; Mook-Kanamori, Dennis O.; Robino, Antonietta; Ruderfer, Douglas; Salvi, Erika; Schick, Ursula M.; Schulz, Christina-Alexandra; Smith, Albert V.; Smith, Jennifer A.; Traglia, Michela; Yerges-Armstrong, Laura M.; Zhao, Wei; Goodarzi, Mark O.; Kraja, Aldi T.; Liu, Chunyu; Wessel, Jennifer; Boerwinkle, Eric; Borecki, Ingrid B.; Bork-Jensen, Jette; Bottinger, Erwin P.; Braga, Daniele; Brandslund, Ivan; Brody, Jennifer A.; Campbell, Archie; Carey, David J.; Christensen, Cramer; Coresh, Josef; Crook, Errol; Curhan, Gary C.; Cusi, Daniele; de Boer, Ian H.; de Vries, Aiko P. J.; Denny, Joshua C.; Devuyst, Olivier; Dreisbach, Albert W.; Endlich, Karlhans; Esko, Tonu; Franco, Oscar H.; Fulop, Tibor; Gerhard, Glenn S.; Gluemer, Charlotte; Gottesman, Omri; Grarup, Niels; Gudnason, Vilmundur; Hansen, Torben; Harris, Tamara B.; Hayward, Caroline; Hocking, Lynne; Hofman, Albert; Hu, Frank B.; Husemoen, Lise Lotte N.; Jackson, Rebecca D.; Jorgensen, Torben; Jorgensen, Marit E.; Kaehoenen, Mika; Kardia, Sharon L. R.; Koenig, Wolfgang; Kooperberg, Charles; Kriebel, Jennifer; Launer, Lenore J.; Lauritzen, Torsten; Lehtimaki, Terho; Levy, Daniel; Linksted, Pamela; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J. F.; Lupo, Antonio; Meisinger, Christine; Melander, Olle; Metspalu, Andres; Mitchell, Paul; Nauck, Matthias; Nuernberg, Peter; Orho-Melander, Marju; Parsa, Afshin; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Porteous, David; Probst-Hensch, Nicole M.; Psaty, Bruce M.; Qi, Lu; Raitakari, Olli T.; Reiner, Alex P.; Rettig, Rainer; Ridker, Paul M.; Rivadeneira, Fernando; Rossouw, Jacques E.; Schmidt, Frank; Siscovick, David; Soranzo, Nicole; Strauch, Konstantin; Toniolo, Daniela; Turner, Stephen T.; Uitterlinden, Andre G.; Ulivi, Sheila; Velayutham, Dinesh; Voelker, Uwe; Volzke, Henry; Waldenberger, Melanie; Wang, Jie Jin; Weir, David R.; Witte, Daniel; Kuivaniemi, Helena; Fox, Caroline S.; Franceschini, Nora; Goessling, Wolfram; Koettgen, Anna; Chu, Audrey Y./titolo:SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function/doi:10.1681%2FASN.2016020131/rivista:Journal of the American Society of Nephrology/anno:2017/pagina_da:981/pagina_a:994/intervallo_pagine:981–994/volume:28, Li, M, Li, Y, Weeks, O, Mijatovic, V, Teumer, A, Huffman, J E, Tromp, G, Fuchsberger, C, Gorski, M, Lyytikäinen, L-P, Nutile, T, Sedaghat, S, Sorice, R, Tin, A, Yang, Q, Ahluwalia, T S, Arking, D E, Bihlmeyer, N A, Böger, C A, Carroll, R J, Chasman, D I, Cornelis, M C, Dehghan, A, Faul, J D, Feitosa, M F, Gambaro, G, Gasparini, P, Giulianini, F, Heid, I, Huang, J, Imboden, M, Jackson, A U, Jeff, J, Jhun, M A, Katz, R, Kifley, A, Kilpeläinen, T O, Kumar, A, Laakso, M, Li-Gao, R, Lohman, K, Lu, Y, Mägi, R, Malerba, G, Mihailov, E, Mohlke, K L, Campbell, A, Hayward, C & Polasek, O & Porteous, D 2017, ' SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function ', Journal of the American Society of Nephrology . https://doi.org/10.1681/ASN.2016020131, Journal of the American Society of Nephrology, 28(3), 981-994. American Society of Nephrology
- Accession number :
- edsair.doi.dedup.....f1884d26857e3271cfaca27cb0d42c00
- Full Text :
- https://doi.org/10.1681/ASN.2016020131