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Vaccination against porcine parvovirus protects against disease, but does not prevent infection and virus shedding after challenge infection with a heterologous virus strain
- Source :
- The Journal of general virology. 90(Pt 10)
- Publication Year :
- 2009
-
Abstract
- The demonstration of field isolates of porcine parvovirus (PPV) that differ genetically and antigenically from vaccine strains of PPV raises the question of whether the broadly used inactivated vaccines can still protect sows against the novel viruses. Ten specific-pathogen-free primiparous sows were assigned to three groups and were vaccinated with one of two vaccines based on the old vaccine strains, or served as non-vaccinated controls. After insemination, all sows were challenged with the prototype genotype 2 virus, PPV-27a, on gestation day 41; fetuses were delivered on gestation day 90 and examined for virus infection. The fetuses of the vaccinated sows were protected against disease, but both the vaccinated and the non-vaccinated sows showed a marked increase in antibody titres after challenge infection, indicating replication of the challenge virus. All sows (vaccinated and non-vaccinated) shed the challenge virus for at least 10 days after infection, with no difference in the pattern or duration of virus shedding.
- Subjects :
- Porcine parvovirus
Swine
animal diseases
Antibodies, Viral
Virus
Parvoviridae Infections
Parvovirus
Immunity
Neutralization Tests
Pregnancy
Virology
Animals
Viral shedding
Antigens, Viral
Swine Diseases
biology
Vaccination
Rectum
food and beverages
Viral Vaccines
Hemagglutination Inhibition Tests
biology.organism_classification
Infectious Disease Transmission, Vertical
Virus Shedding
Viral replication
Immunology
Female
Viral disease
Subjects
Details
- ISSN :
- 14652099
- Volume :
- 90
- Issue :
- Pt 10
- Database :
- OpenAIRE
- Journal :
- The Journal of general virology
- Accession number :
- edsair.doi.dedup.....f17a55aaab95ac69db1cec4db2c81680