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Ustiloxins, antimitotic cyclic peptides from false smut balls on rice panicles caused by Ustilaginoidea virens
- Source :
- The Journal of antibiotics. 47(7)
- Publication Year :
- 1994
-
Abstract
- Ustiloxins A (1a), B (1b), C (1c), D (1d) and E (1e), antimitotic peptides, have been isolated from the water extract of false smut balls caused on the panicles of rice plant by a fungus Ustilaginoidea virens. The structure of 1b was assigned from its spectral property and its amino acid analysis in relation to 1a whose structure was determined previously by a combination of X-ray crystallographic and amino acid analyses. Structures of 1c and 1d were elucidated by their spectroscopic data, specially based on their 1H and 13C NMR spectra. Bioactivities of these compounds against microtubule assembly as well as mammal, plant and fungal cells have been studied.
- Subjects :
- Antifungal Agents
Stereochemistry
Swine
Molecular Sequence Data
Peptide
Antineoplastic Agents
Spectrometry, Mass, Fast Atom Bombardment
Microtubules
Peptides, Cyclic
Drug Discovery
Tumor Cells, Cultured
Animals
Humans
Amino Acid Sequence
Peptide sequence
Plant Diseases
Pharmacology
chemistry.chemical_classification
biology
Fungi
Ustilaginoidea virens
Oryza
Fungi imperfecti
Mycotoxins
biology.organism_classification
Cyclic peptide
Amino acid
Anti-Bacterial Agents
chemistry
Smut
Microtubule Proteins
Villosiclava
Peptides
Subjects
Details
- ISSN :
- 00218820
- Volume :
- 47
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- The Journal of antibiotics
- Accession number :
- edsair.doi.dedup.....f1798a64b6ed28226404e05369aa39dd