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Circadian modulation of interval timing in mice
- Source :
- Brain Research. 1370:154-163
- Publication Year :
- 2011
- Publisher :
- Elsevier BV, 2011.
-
Abstract
- Temporal perception is fundamental to environmental adaptation in humans and other animals. To deal with timing and time perception, organisms have developed multiple systems that are active over a broad range of order of magnitude, the most important being circadian timing, interval timing and millisecond timing. The circadian pacemaker is located in the suprachiasmatic nuclei (SCN) of the hypothalamus, and is driven by a self-sustaining oscillator with a period close to 24h. Time estimation in the second-to-minutes range--known as interval timing--involves the interaction of the basal ganglia and the prefrontal cortex. In this work we tested the hypothesis that interval timing in mice is sensitive to circadian modulations. Animals were trained following the peak-interval (PI) procedure. Results show significant differences in the estimation of 24-second intervals at different times of day, with a higher accuracy in the group trained at night, which were maintained under constant dark (DD) conditions. Interval timing was also studied in animals under constant light (LL) conditions, which abolish circadian rhythmicity. Mice under LL conditions were unable to acquire temporal control in the peak interval procedure. Moreover, short time estimation in animals subjected to circadian desynchronizations (modeling jet lag-like situations) was also affected. Taken together, our results indicate that short-time estimation is modulated by the circadian clock.
- Subjects :
- medicine.medical_specialty
Period (gene)
Circadian clock
Biology
Mice
Biological Clocks
Internal medicine
medicine
Animals
Learning
Circadian rhythm
Prefrontal cortex
Molecular Biology
Behavior, Animal
Suprachiasmatic nucleus
Teaching
General Neuroscience
Time perception
Circadian Rhythm
Mice, Inbred C57BL
Endocrinology
Light effects on circadian rhythm
Hypothalamus
Time Perception
Suprachiasmatic Nucleus
Neurology (clinical)
Neuroscience
Developmental Biology
Subjects
Details
- ISSN :
- 00068993
- Volume :
- 1370
- Database :
- OpenAIRE
- Journal :
- Brain Research
- Accession number :
- edsair.doi.dedup.....f1756a7a729948ce8d0f9ce55c5ac800