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Coordination of Thiosemicarbazones and Bis(thiosemicarbazones) to Bismuth(III) as a Strategy for the Design of Metal‐Based Antibacterial Agents
- Source :
- Chemistry & Biodiversity. 9:1955-1966
- Publication Year :
- 2012
- Publisher :
- Wiley, 2012.
-
Abstract
- Complexes [Bi(2Fo4Ph)Cl(2)] (1), [Bi(2Ac4Ph)Cl(2)] (2), [Bi(2Bz4Ph)Cl(2)] (3), [Bi(H(2)Gy3DH)Cl(3)] (4), [Bi(H(2)Gy4Et)(OH)(2)Cl] (5), and [Bi(H(2)Gy4Ph)Cl(3)] (6) were prepared with pyridine-2-carbaldehyde 4-phenylthiosemicarbazone (H2Fo4Ph), 1-(pyridin-2-yl)ethanone 4-phenylthiosemicarbazone (H2Ac4Ph), phenyl(pyridin-2-yl)methanone 4-phenylthiosemicarbazone (H2Bz4Ph), as well as with glyoxaldehyde bis(thiosemicarbazone) (H(2)Gy4DH) and its 4-Et (H(2)Gy4Et) and 4-Ph (H(2)Gy4Ph) derivatives. The complexes exhibited antibacterial activities against Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and Pseudomonas aeruginosa. Coordination to Bi(III) proved to be an effective strategy to increase the antibacterial activity of the thiosemicarbazones and bis(thiosemicarbazones).
- Subjects :
- Models, Molecular
Thiosemicarbazones
Staphylococcus aureus
Magnetic Resonance Spectroscopy
Stereochemistry
chemistry.chemical_element
Bioengineering
Microbial Sensitivity Tests
Crystallography, X-Ray
medicine.disease_cause
Biochemistry
Medicinal chemistry
Enterococcus faecalis
Bismuth
Metal
chemistry.chemical_compound
Coordination Complexes
Staphylococcus epidermidis
medicine
Molecular Biology
Semicarbazone
Bacteria
Molecular Structure
biology
Pseudomonas aeruginosa
General Chemistry
General Medicine
biology.organism_classification
Anti-Bacterial Agents
chemistry
visual_art
visual_art.visual_art_medium
Molecular Medicine
Antibacterial activity
Enterococcus
Subjects
Details
- ISSN :
- 16121880 and 16121872
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Chemistry & Biodiversity
- Accession number :
- edsair.doi.dedup.....f172c1ff6f14acc387b368d770672416