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The hispanic landscape of triple negative breast cancer
- Source :
- Critical reviews in oncology/hematology. 155
- Publication Year :
- 2019
-
Abstract
- Triple-negative breast cancer (TNBC) is a heterogeneous and complex disease characterized by the absence of immunohistochemical expression of estrogen receptor, progesterone receptor and HER2. These breast tumors present an aggressive biology and offer few opportunities to be treated with targeted therapy resulting in bad disease outcomes. The epidemiology of TNBC is intriguing where the understanding of its biology has progressed quickly. One of the peculiarities of this type of cancer is a high prevalence in Afrodescendants and Hispanic patients compared to Caucasian women. In this review we describe some features of TNBC, focusing in the Hispanic population, such as epidemiological, clinicopathological features and molecular features and the correlation between TNBC prevalence and the human development index.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Receptor, ErbB-2
medicine.medical_treatment
Estrogen receptor
Triple Negative Breast Neoplasms
Targeted therapy
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Epidemiology
Progesterone receptor
medicine
Humans
Triple-negative breast cancer
business.industry
Cancer
Hematology
Hispanic or Latino
medicine.disease
030104 developmental biology
Receptors, Estrogen
030220 oncology & carcinogenesis
Immunohistochemistry
Female
business
Receptors, Progesterone
Subjects
Details
- ISSN :
- 18790461
- Volume :
- 155
- Database :
- OpenAIRE
- Journal :
- Critical reviews in oncology/hematology
- Accession number :
- edsair.doi.dedup.....f16d10e6f78714b83c00f9d9e03af117