Back to Search
Start Over
Neurotrophin receptor immunostaining in the vestibular nuclei of rats
- Source :
- NeuroReport. 14:851-855
- Publication Year :
- 2003
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2003.
-
Abstract
- The distribution of high-affinity neurotrophin receptors in cells of the vestibular nuclear complex and its subnuclei of adult rats was examined. We noted a high density of tyrosine kinase (Trk) A- and B- and a lower density of TrkC-immunostained cells. In particular, long, intensely labelled immunostained-TrkB fibres formed networks in the neuropil. Both TrkA- and TrkB-immunostained cells were widely distributed in the lateral, medial and spinal vestibular nuclei, and were less frequently seen in the superior vestibular nucleus, x and y subnuclei. However, immunostaining for TrkC was weak in many cells within the vestibular nuclei. The widespread and abundant neuronal distribution of Trk receptors predicts that their associated neurotrophins exert significant effects on individual cells within the vestibular nuclei.
- Subjects :
- medicine.medical_specialty
Neuropil
animal structures
Blotting, Western
Tropomyosin receptor kinase A
Tropomyosin receptor kinase C
Rats, Sprague-Dawley
Vestibular nuclei
Internal medicine
otorhinolaryngologic diseases
medicine
Animals
Receptor, trkB
Receptor, trkC
Superior vestibular nucleus
Receptor, trkA
Neurons
biology
General Neuroscience
Vestibular pathway
Vestibular Nuclei
Immunohistochemistry
Rats
Endocrinology
medicine.anatomical_structure
nervous system
Trk receptor
biology.protein
Female
sense organs
Neurotrophin
Subjects
Details
- ISSN :
- 09594965
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- NeuroReport
- Accession number :
- edsair.doi.dedup.....f1638e16d793f50c139f4b125565e167