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Dorsal and ventral striatal neuronal subpopulations differentially disrupt male mouse copulatory behavior
- Source :
- European neuropsychopharmacology, 49
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- The specific role of the striatum, especially its dorsolateral (DLS) and dorsomedial (DMS) parts, in male copulatory behavior is still debated. In order to clarify their contribution to male sexual behavior, we specifically ablated the major striatal neuronal subpopulations, direct and indirect medium spiny neurons (dMSNs and iMSNs) in DMS or DLS, and dMSNs, iMSNs and cholinergic interneurons in nucleus accumbens (NAc), The main results of this study can be summarized as follows: In DMS, dMSN ablation causes a reduction in the percent of mice that mount a receptive female, and a complex alteration in the parameters of the copulatory performance, that is largely opposite to the alterations induced by iMSN ablation. In DLS, dMSN ablation causes a widespread alteration in the copulatory behavior parameters, that tends to disappear at repetition of the test; iMSN ablation induces minor copulatory behavior alterations that are complementary to those observed after dMSN ablation. In NAc, dMSN ablation causes a marked reduction in the percent of mice that mount a receptive female and a disruption of copulatory behavior, while iMSN ablation induces minor copulatory behavior alterations that are opposite to those observed with dMSN ablation, and cholinergic neuron ablation induces a selective decrease in mount latency. Overall, present data point to a complex region and cell-specific contribution to copulatory behavior of the different neuronal subpopulations of both dorsal and ventral striatum, with a prominent role of the dMSNs of the different subregions.<br />info:eu-repo/semantics/published
- Subjects :
- Male
Sexual behavior
Génétique moléculaire
Dopamine
Striatum
Nucleus accumbens
Biology
Indirect pathway of movement
Medium spiny neuron
Indirect pathway
Mice
03 medical and health sciences
0302 clinical medicine
Interneurons
medicine
Animals
Pharmacology (medical)
Direct pathway of movement
Cholinergic neuron
Biological Psychiatry
Neurons
Pharmacology
Neurophysiologie
Ventral striatum
Biologie moléculaire
Direct pathway
Corpus Striatum
030227 psychiatry
Neostriatum
Psychiatry and Mental health
medicine.anatomical_structure
Neurology
Ventral Striatum
Cholinergic
Female
Neurology (clinical)
Neuroscience
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 0924977X
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- European Neuropsychopharmacology
- Accession number :
- edsair.doi.dedup.....f163522f7376bbc93d9a8ffbb956a4bd