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PAX5 P80R mutation identifies a novel subtype of B-cell precursor acute lymphoblastic leukemia with favorable outcome
- Source :
- Blood, Vol. 133, No 3 (2019) pp. 280-284
- Publication Year :
- 2019
- Publisher :
- American Society of Hematology, 2019.
-
Abstract
- TO THE EDITOR: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a rare aggressive malignancy in adults. BCP-ALL is frequently characterized by recurrent chromosomal translocations that deregulate proto-oncogenes or result in fusion genes encoding chimeric oncoproteins.[1][1] Gene
- Subjects :
- Adult
Homologous
0301 basic medicine
Immunology
Chromosomal translocation
Malignancy
medicine.disease_cause
PAX5 Transcription Factor/genetics
Biochemistry
Cohort Studies
Fusion gene
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
Acute lymphocytic leukemia
Local/genetics/pathology/therapy
medicine
Humans
B cell
ddc:616
Transplantation
Mutation
business.industry
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/classification/genetics/pathology/therapy
Cell Biology
Hematology
Prognosis
medicine.disease
Survival Rate
Neoplasm Recurrence
030104 developmental biology
medicine.anatomical_structure
Cancer research
PAX5
business
Follow-Up Studies
Stem Cell Transplantation
030215 immunology
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 133
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....f15d38b20f81bcbea8e85040a96a264f