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Leptin inhibits mitogen-induced proliferation of peripheral T lymphocytes from Holstein cows
- Source :
- Veterinary journal (London, England : 1997). 176(3)
- Publication Year :
- 2006
-
Abstract
- This study examined the mitogenic response of bovine peripheral T lymphocytes to leptin, a pleiotropic hormone regulating food intake and energy expenditure. Leptin alone slightly suppressed proliferation of T lymphocytes in the presence of concanavalin A (ConA). Leptin also inhibited proliferation of T lymphocytes induced by anti-CD3 antibody. ConA treatment activated some protein kinases, including p44/p42MAPK and Akt/PKB, while anti-CD3 antibody treatment increased mRNA expression of suppressor of cytokine signalling (SOCS) 3, interferon (IFN)γ, interleukin (IL) 2 and IL4 in T lymphocytes. Leptin alone increased only SOCS3 mRNA expression. Simultaneous treatment with mitogens and leptin enhanced IFNγ mRNA expression but decreased IL2 mRNA expression, without any synergistic effect on phosphorylation of protein kinases or mRNA expression of SOCS3 and IL4. These results suggest that leptin modulates bovine T lymphocyte functions.
- Subjects :
- Leptin
medicine.medical_specialty
T-Lymphocytes
Lymphocyte Activation
Suppressor of cytokine signalling
Internal medicine
medicine
Concanavalin A
Animals
SOCS3
Interleukin 4
Cell Proliferation
General Veterinary
biology
digestive, oral, and skin physiology
Interleukin
T lymphocyte
Endocrinology
Mitogen-activated protein kinase
biology.protein
Cytokines
Animal Science and Zoology
Cattle
Female
Mitogens
Protein Kinases
Signal Transduction
Subjects
Details
- ISSN :
- 10900233
- Volume :
- 176
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Veterinary journal (London, England : 1997)
- Accession number :
- edsair.doi.dedup.....f15a329bb771662b3f6f03bab6ff3091