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Computational fluid dynamics in Fontan patients to evaluate power loss during simulated exercise
- Source :
- Heart, 100, 696-701, Heart, 100, 9, pp. 696-701, Heart, 100(9), 696-701. BMJ Publishing Group
- Publication Year :
- 2014
-
Abstract
- Item does not contain fulltext OBJECTIVE: Exercise intolerance is common in total cavopulmonary connection (TCPC) patients. It has been suggested that power loss (Ploss) inside the TCPC plays a role in reduced exercise performance. Our objective is to establish the role of Ploss inside the TCPC during increased flow, simulating exercise in a patient-specific way. METHODS: Cardiac MRI (CMR) was used to obtain flow rates from the caval veins during rest and increased flow, simulating exercise with dobutamine. A 3D reconstruction of the TCPC was created using CMR data. Computational fluid dynamics (CFD) simulations were performed to calculate Ploss inside the TCPC structure for rest and stress conditions. To reflect the flow distribution during exercise, a condition where inferior caval vein (IVC) flow was increased twofold compared with rest was added. 29 TCPC patients (15 intra-atrial lateral tunnel (ILT) and 14 extracardiac conduit (ECC)) were included. RESULTS: Mean Ploss at rest was 1.36 +/- 0.94 (ILT) and 3.20 +/- 1.26 (ECC) mW/m(2) (p
- Subjects :
- Heart Defects, Congenital
Male
medicine.medical_specialty
medicine.medical_treatment
Extracardiac conduit
Cardiac index
Magnetic Resonance Imaging, Cine
Total cavopulmonary connection
Exercise intolerance
Computational fluid dynamics
Fontan Procedure
Fontan procedure
Imaging, Three-Dimensional
Internal medicine
medicine
Humans
Child
Netherlands
Electronic Data Processing
Power loss
Exercise Tolerance
business.industry
Other Research Radboud Institute for Health Sciences [Radboudumc 0]
Surgery
Survival Rate
Cross-Sectional Studies
Treatment Outcome
Exercise Test
cardiovascular system
Cardiology
Female
Dobutamine
Venae Cavae
medicine.symptom
Cardiology and Cardiovascular Medicine
business
Blood Flow Velocity
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 13556037
- Database :
- OpenAIRE
- Journal :
- Heart, 100, 696-701, Heart, 100, 9, pp. 696-701, Heart, 100(9), 696-701. BMJ Publishing Group
- Accession number :
- edsair.doi.dedup.....f152689f94c09b03b7efbcb2acb50572