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Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds
- Source :
- Bioorganic & Medicinal Chemistry Letters. 18:4499-4502
- Publication Year :
- 2008
- Publisher :
- Elsevier BV, 2008.
-
Abstract
- Hydrolysis of DNA is of increasing importance in biotechnology and medicine. In this Letter, we present the DNA-cleavage potential of metal-free hydroxylamines and oximes as new members of nucleic acid cleavage agents.
- Subjects :
- Glycerol
Clinical Biochemistry
Pharmaceutical Science
Hydroxylamines
Cleavage (embryo)
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Hydrolysis
Hydroxylamine
Nucleic Acids
Oximes
Drug Discovery
Organic chemistry
Molecular Biology
Bond cleavage
Deoxyribonucleases
Distamycins
Organic Chemistry
DNA
Hydrogen-Ion Concentration
Oxime
Chemistry
Kinetics
chemistry
Metals
Drug Design
Solvents
Nucleic acid
Nucleic Acid Conformation
Molecular Medicine
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....f13ee2772c4fdc41da8791ace76fa350
- Full Text :
- https://doi.org/10.1016/j.bmcl.2008.07.052