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Un-functionalized Gold Nanoparticles as a Simple Colorimetric Probe for Sensitive and Selective Detection of Dopamine

Authors :
Nelson Torto
Nokuthula Khanyile
Rui W. M. Krause
Sibulelo Vilakazi
Source :
South African Journal of Chemistry, Volume: 72, Pages: 207-214, Published: 2019
Publication Year :
2019
Publisher :
Academy of Science of South Africa, 2019.

Abstract

A dopamine (DA) colorimetric probe based on the growth and aggregation of un-functionalized gold nanoparticles (AuNPs) is reported. Upon addition of AuNPs to dopamine at various concentrations, the shape, size and colour change of the nanoparticles results in spectral shifts to higher wavelengths and hence colour change is the mode of detection. The colour change can be easily observed by the naked eye from as low as 5.0 nM DA, even under sub-optimal conditions. Under optimal pH conditions the calculated limit of detection was 2.5 nM (3σ). The probe was successfully applied to whole blood sample and showed good selectivity and sensitivity towards DA. The simple, sensitive and selective probe could be an excellent alternative for on-site and immediate detection of DA without the use of instrumentation and would thus be useful for rapid diagnostic applications.

Details

ISSN :
1996840X and 03794350
Volume :
72
Database :
OpenAIRE
Journal :
South African Journal of Chemistry
Accession number :
edsair.doi.dedup.....f13b1bc21548d3e480adf001976aa030
Full Text :
https://doi.org/10.17159/0379-4350/2019/v72a27