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Simultaneous Changes of Spatial Memory and Spine Density after Intrahippocampal Administration of Fibrillar Aβ1–42 to the Rat Brain
- Source :
- BioMed Research International, Vol 2014 (2014), BioMed Research International
- Publication Year :
- 2014
- Publisher :
- Hindawi Limited, 2014.
-
Abstract
- Several animal models of Alzheimer’s disease have been used in laboratory experiments. Intrahippocampal injection of fibrillar amyloid-beta (fAβ) peptide represents one of the most frequently used models, mimicking Aβdeposits in the brain. In our experiment synthetic fAβ1–42peptide was administered to rat hippocampus. The effect of the Aβpeptide on spatial memory and dendritic spine density was studied. The fAβ1–42-treated rats showed decreased spatial learning ability measured in Morris water maze (MWM). Simultaneously, fAβ1–42caused a significant reduction of the dendritic spine density in the rat hippocampus CA1 region. The decrease of learning ability and the loss of spine density were in good correlation. Our results prove that both methods (MWM and dendritic spine density measurement) are suitable for studying Aβ-triggered neurodegeneration processes.
- Subjects :
- Male
Amyloid
Pathology
medicine.medical_specialty
Dendritic spine
Article Subject
Dendritic Spines
Golgi Apparatus
Hippocampus
Morris water navigation task
lcsh:Medicine
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Rats, Wistar
Maze Learning
CA1 Region, Hippocampal
Spatial Memory
030304 developmental biology
SPINE (molecular biology)
0303 health sciences
Amyloid beta-Peptides
General Immunology and Microbiology
Chemistry
Pyramidal Cells
Neurodegeneration
lcsh:R
General Medicine
medicine.disease
Rat brain
Peptide Fragments
Spatial learning
Neuroscience
030217 neurology & neurosurgery
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23146141 and 23146133
- Volume :
- 2014
- Database :
- OpenAIRE
- Journal :
- BioMed Research International
- Accession number :
- edsair.doi.dedup.....f139ffa49c9e34fe0991032932ffaf36