177: Interplay between right ventricular function and cardiac resynchronisation therapy: An Analysis of the CARE-HF trial

Background Cardiac resynchronization therapy (CRT) prolongs survival in appropriately selected patients with heart failure. Right ventricular (RV) dysfunction is associated with a worse prognosis in this setting but it is not clear whether it influences the clinical response to CRT. Method and Results Of 813 patients enrolled in the Cardiac Resynchronization-Heart Failure (CARE-HF) study, 688 had tricuspid plane systolic excursion (TAPSE) measured at baseline and 345 of these were assigned to CRT. Their median (IQR) age was 66 (58-71) years, left ventricular (LV) ejection fraction was 24 (21-28)% and TAPSE was 19 (16-22)mm. Baseline LV function and size and QRS duration were similar amongst TAPSE tertiles but those in the worst tertile (TAPSE Conclusion RV dysfunction is a powerful determinant of prognosis amongst candidates for CRT, regardless of treatment assigned: CRT improved prognostic in patients with RV dysfunction despite less improvement in LV remodelling.