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Rituximab-related viral infections in lymphoma patients
- Source :
- Leukemia & Lymphoma. 48:1307-1312
- Publication Year :
- 2007
- Publisher :
- Informa UK Limited, 2007.
-
Abstract
- Recently, a human/mouse chimeric monoclonal antibody, rituximab, has been successfully used to treat cases of B-cell non-Hodgkin's lymphoma and some autoimmune diseases. However, several viral infections related to rituximab have been reported in the literature, but were not well characterized. To further investigate this topic, relevant English language studies were identified through Medline. There were 64 previously reported cases of serious viral infection after rituximab treatment. The median age of the cases was 61 years (range: 21 - 79). The median time period from the start of rituximab treatment to viral infection diagnosis was 5.0 months (range: 1 - 20). The most frequently experienced viral infections were hepatitis B virus (HBV) (39.1%, n = 25), cytomegalovirus infection (CMV) (23.4%, n = 15), varicella-zoster virus (VZV) (9.4%, n = 6), and others (28.1%, n = 18). Of the patients with HBV infections, 13 (52.0%) died due to hepatic failure. Among the 39 cases that had viral infections other than HBV, 13 died due to these specific infections. In this study, about 50% of the rituximab-related HBV infections resulted in death, whereas this was the case in only 33% of the cases with other infections. Close monitoring for viral infection, particularly HBV and CMV, in patients treated with rituximab should be recommended.
- Subjects :
- Adult
Cancer Research
Lymphoma
medicine.drug_class
MEDLINE
Monoclonal antibody
Antibodies, Monoclonal, Murine-Derived
Chickenpox
immune system diseases
Cause of Death
hemic and lymphatic diseases
parasitic diseases
medicine
Humans
Aged
Cause of death
biology
business.industry
Liver failure
Antibodies, Monoclonal
Hematology
Middle Aged
Hepatitis B
medicine.disease
Non-Hodgkin's lymphoma
Oncology
Virus Diseases
Cytomegalovirus Infections
Monoclonal
Immunology
biology.protein
Rituximab
Antibody
business
Liver Failure
medicine.drug
Subjects
Details
- ISSN :
- 10292403 and 10428194
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Leukemia & Lymphoma
- Accession number :
- edsair.doi.dedup.....f12a98e93150e0081de652418577e228