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Biomarkers of aggressive pituitary adenomas
- Source :
- Journal of Molecular Endocrinology. 49:R69-R78
- Publication Year :
- 2012
- Publisher :
- Bioscientifica, 2012.
-
Abstract
- Pituitary adenomas exhibit a wide range of behaviors. The prediction of aggressive or malignant behavior in pituitary adenomas remains challenging; however, the utility of biomarkers is rapidly evolving. In this review, we discuss potential biomarkers as they relate to aggressive behavior in pituitary adenomas. While detailed histological subtyping remains the best independent predictor of aggressive behavior in the majority of cases, evidence suggests that the additional analyses of FGFR4, MMP, PTTG, Ki-67, p53, and deletions in chromosome 11 may contribute to decisions concerning management of aggressive pituitary adenomas.
- Subjects :
- Adenoma
medicine.medical_specialty
Independent predictor
Bioinformatics
Endocrinology
Internal medicine
Biomarkers, Tumor
medicine
Humans
Pituitary Neoplasms
Receptor, Fibroblast Growth Factor, Type 4
Molecular Biology
business.industry
Chromosomes, Human, Pair 11
Genes, p53
Matrix Metalloproteinases
Neoplasm Proteins
Securin
MicroRNAs
Ki-67 Antigen
Potential biomarkers
Mutation
Chromosome Deletion
Carrier Proteins
business
Subjects
Details
- ISSN :
- 14796813 and 09525041
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Journal of Molecular Endocrinology
- Accession number :
- edsair.doi.dedup.....f129b6f4cf5c8bfd4e5a08d4e8de6b63