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A Range of Cancers Is Associated with the rs6983267 Marker on Chromosome 8
- Source :
- Cancer Research. 68:9982-9986
- Publication Year :
- 2008
- Publisher :
- American Association for Cancer Research (AACR), 2008.
-
Abstract
- Several genome-wide searches for common cancers have lead to the identification of a small number of loci that harbor low-risk cancer susceptibility markers. One marker, rs6983267 on chromosome 8q24, has been linked to both colon and prostate cancer, and is therefore a good candidate for a multicancer susceptibility marker. To determine the range of cancer sites associated with rs6983267, we genotyped 7,665 cases of cancer, representing 11 common cancer sites, and 1,910 controls. A significant odds ratio (OR) was observed for prostate cancer for carriers of genotype GG [OR, 1.77; 95% confidence interval (CI), 1.47–2.13]. The homozygote OR was higher for tumors with Gleason score 8 to 10 (OR, 1.94; 95% CI, 1.18–3.20) than for tumors with Gleason score 7 and below (OR, 1.65; 95% CI, 1.31–2.08). Significantly elevated (homozygote) ORs were observed for 4 other cancer sites, including colon (OR, 1.36; 95% CI, 1.08–1.72), kidney (OR, 1.52; 95% CI, 1.12–2.05), thyroid (OR, 1.37; 95% CI, 1.02–1.82), and larynx (OR, 1.39; 95% CI, 1.02–1.90). Information was available on family histories of cancer for eight sites. For six of the eight sites (prostate, breast, bladder, larynx, lung, and kidney), the homozygote ORs were higher for cases with a positive family history (at least one first-degree with any cancer) than for cases with unaffected first-degree relatives. Our results suggest that the range of cancers associated with the rs6983267 marker might be larger than previously thought. [Cancer Res 2008;68(23):9982–6]
- Subjects :
- Adult
Genetic Markers
Male
Cancer Research
medicine.medical_specialty
Pathology
Genotype
Polymorphism, Single Nucleotide
Gastroenterology
Young Adult
Prostate cancer
Polymorphism (computer science)
Prostate
Neoplasms
Internal medicine
medicine
Humans
Family history
Young adult
Aged
Aged, 80 and over
business.industry
Cancer
Odds ratio
Middle Aged
medicine.disease
medicine.anatomical_structure
Oncology
Female
business
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....f1215cccc8d630196347b72200a60b77