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Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD)
- Source :
- Short, B, Carson, S, Devlin, A-C, Reihill, J A, Crilly, A, MacKay, W, Ramage, G, Williams, C, Lundy, F T, McGarvey, L P, Thornbury, K D & Martin, L 2021, ' Non-typeable Haemophilus influenzae chronic colonization in chronic obstructive pulmonary disease (COPD) ', Critical Reviews in Microbiology, vol. 47, no. 2, pp. 192-205 . https://doi.org/10.1080/1040841X.2020.1863330
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- Haemophilus influenzae is the most common cause of bacterial infection in the lungs of chronic obstructive pulmonary disease (COPD) patients and contributes to episodes of acute exacerbation which are associated with increased hospitalization and mortality. Due to the ability of H. influenzae to adhere to host epithelial cells, initial colonization of the lower airways can progress to a persistent infection and biofilm formation. This is characterized by changes in bacterial behaviour such as reduced cellular metabolism and the production of an obstructive extracellular matrix (ECM). Herein we discuss the multiple mechanisms by which H. influenzae contributes tothe pathogenesis of COPD. In particular, mechanisms that facilitate bacterial adherence to host airway epithelial cells, biofilm formation, and microbial persistence through immune system evasion and antibiotic tolerance will be discussed.
- Subjects :
- 0301 basic medicine
COPD
Exacerbation
business.industry
NTHi
030106 microbiology
Pulmonary disease
General Medicine
medicine.disease
medicine.disease_cause
Chronic colonization
Haemophilus influenzae
Applied Microbiology and Biotechnology
Microbiology
biofilm
respiratory tract diseases
03 medical and health sciences
030104 developmental biology
Immunology
medicine
Non typeable
bacterial adherence
business
Subjects
Details
- ISSN :
- 15497828 and 1040841X
- Volume :
- 47
- Database :
- OpenAIRE
- Journal :
- Critical Reviews in Microbiology
- Accession number :
- edsair.doi.dedup.....f119a7a145cf6dd72ffc805044bd6f02