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CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells
- Source :
- Hansen, A S, Biltoft, M, Bundgaard, B, Bohn, A B, Møller, B K & Höllsberg, P B 2019, ' CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells ', Cytokine, vol. 113, pp. 466-469 . https://doi.org/10.1016/j.cyto.2018.06.030
- Publication Year :
- 2019
-
Abstract
- CD46 is an important immune regulatory receptor with dual functions, however, the CD46 isoform distribution and the effect of CD46 activation on the cytokine production in monocytes and monocyte-derived dendritic cells (moDCs) is unclear. Here, we show that CD46 activation of moDCs downregulates LPS-induced CXCL-10 expression, while the expression of CXCL-10 in monocytes is unaffected. Furthermore, the differentiation of moDCs induces a switch towards dominance of CYT-2 isoforms of CD46. These data indicate that CD46 activation exerts different functions in monocytes and moDCs and this correlates with a switch in CD46 isoform expression upon differentiation of moDCs.
- Subjects :
- Lipopolysaccharides
0301 basic medicine
Gene isoform
medicine.medical_treatment
viruses
Immunology
Down-Regulation
Biochemistry
Monocytes
Membrane Cofactor Protein
03 medical and health sciences
0302 clinical medicine
Immune system
CXCL-10
medicine
Humans
Immunology and Allergy
Receptor
Molecular Biology
CD46
Chemistry
Monocyte derived
Cell Differentiation
Dendritic Cells
Hematology
female genital diseases and pregnancy complications
Cell biology
Chemokine CXCL10
030104 developmental biology
Cytokine
030220 oncology & carcinogenesis
Monocyte-derived dendritic cells
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Hansen, A S, Biltoft, M, Bundgaard, B, Bohn, A B, Møller, B K & Höllsberg, P B 2019, ' CD46 activation induces distinct CXCL-10 response in monocytes and monocyte-derived dendritic cells ', Cytokine, vol. 113, pp. 466-469 . https://doi.org/10.1016/j.cyto.2018.06.030
- Accession number :
- edsair.doi.dedup.....f11618282790d3f75fd787490b03f241