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Changes in glucose turnover parameters during muscular exercise: role of age
- Source :
- Archives of Gerontology and Geriatrics. 10:253-260
- Publication Year :
- 1990
- Publisher :
- Elsevier BV, 1990.
-
Abstract
- In a study of ten young and seven elderly healthy men we have performed an oral glucose tolerance test (75 g) and employed a euglycemic hyperinsulinemic (0.25 mU× kg/min) glucose clamp technique in order to determine insulin sensitivity. This latter experimental protocol consisted of 120 min of euglycemic clamp followed by 60 min in which the clamp and a mild muscular exercise (35% VO 2 max ) were combined. d -[ 3 H]glucose infusion allowed a determination of the glucose turnover parameters. Our results show that in elderly subjects glucose disappearance rate and glucose metabolic clearance rate are significantly lower during both clamp, and clamp + muscular exercise studies. On the contrary, hepatic glucose production was similar under both conditions and was independent of age.
- Subjects :
- Senescence
Aging
Glucose tolerance test
medicine.medical_specialty
Health (social science)
medicine.diagnostic_test
business.industry
Insulin
medicine.medical_treatment
Physical exercise
Metabolism
Glucose clamp technique
Carbohydrate
Endocrinology
Clamp
Internal medicine
medicine
Geriatrics and Gerontology
business
Gerontology
Subjects
Details
- ISSN :
- 01674943
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Archives of Gerontology and Geriatrics
- Accession number :
- edsair.doi.dedup.....f115425f2828b06f70317ecab40b2845