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Dehydration Study of Piracetam Co-Crystal Hydrates
- Source :
- Journal of pharmaceutical sciences. 107(11)
- Publication Year :
- 2018
-
Abstract
- A hydrate of co-crystal of piracetam and 3,5-dihydroxybenzoic acid was obtained via crystallization from water. Single-crystal X-ray data show that piracetam/3,5-dihydroxybenzoic acid tetrahydrate (P35TH) crystallizes in the triclinic system with a P1 space group. The physicochemical properties of co-crystal hydrate were characterized using powder X-ray diffractometry, differential scanning calorimetry (DSC), thermogravimetric analyzer (TGA), and FTIR spectroscopy. The dehydration kinetics of P35TH was monitored at various temperatures and heating rates by DSC and TGA. Activation energy of P35TH dehydration was obtained using temperature ramp DSC, isothermal and nonisothermal TGA methods. Kinetic analysis of isothermal TGA data was fitted to various solid-state reaction models. Mechanistic models derived from isothermal dehydration kinetic data are best described as a 2-dimensional diffusion mechanism. A correlation was noted between the dehydration behavior and the bonding environment of the water molecules in the crystal structure. This study is a good demonstration of complexity of co-crystal hydrate and their dehydration behavior.
- Subjects :
- Models, Molecular
Thermogravimetric analysis
Materials science
Pharmaceutical Science
Triclinic crystal system
010402 general chemistry
Crystallography, X-Ray
030226 pharmacology & pharmacy
01 natural sciences
Isothermal process
law.invention
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Differential scanning calorimetry
law
Spectroscopy, Fourier Transform Infrared
medicine
Hydroxybenzoates
Dehydration
Crystallization
Desiccation
Tetrahydrate
Calorimetry, Differential Scanning
technology, industry, and agriculture
Temperature
Water
Resorcinols
medicine.disease
Piracetam
0104 chemical sciences
Kinetics
Neuroprotective Agents
chemistry
Thermogravimetry
Physical chemistry
Hydrate
Subjects
Details
- ISSN :
- 15206017
- Volume :
- 107
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of pharmaceutical sciences
- Accession number :
- edsair.doi.dedup.....f1136c9f3e3e729f0fe83c23280f15d0