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Age and Sex Influence Thyroid Hormone Effects in Target Tissues with Organ-Specific Responses
- Publication Year :
- 2020
-
Abstract
- Age and sex impact prevalence and clinical features of thyroid disease. Thyroid dysfunction occurs with a higher frequency in elderly patients and females. Moreover, age alters clinical presentation of hyper- and hypothyroidism and onset of thyroid hormone (TH) related co-morbidities leading to increased risk for underdiagnosis and maltreatment in the elderly. Rodent models allow further insights into mechanisms of age- and sex-dependent TH action in target tissues. In this review, we summarize findings from mouse studies showing distinct effects of age and sex on systemic versus organ-specific TH action and discuss their wider implication for clinical care.
- Subjects :
- Male
Aging
Thyroid Hormones
Endocrinology, Diabetes and Metabolism
Medizin
Physiology
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Age and sex
03 medical and health sciences
Mice
0302 clinical medicine
Endocrinology
Sex Factors
Thyroid dysfunction
Organ specific
Internal Medicine
medicine
Animals
Clinical care
business.industry
Thyroid disease
Thyroid
Age Factors
General Medicine
medicine.disease
Thyroid Diseases
Increased risk
medicine.anatomical_structure
Female
business
Hormone
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....f10dbbeda87227dded97bde961869c20