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InvivoPen: A novel plasma source for in vivo cancer treatment
- Source :
- Journal of Cancer
- Publication Year :
- 2020
- Publisher :
- Ivyspring International Publisher, 2020.
-
Abstract
- Background: With the anti-cancer efficacies of cold atmospheric plasma being increasingly recognized in vitro, a demand on creating an effective tool feasible for in vivo animal treatment has emerged. Methods: Through the use of co-axial needles with different calibers in diameter, we designed a novel in situ ejection source of cold atmospheric plasma, namely invivoPen, for animal experiments. It punches just a single pinhole that could considerably ease the complexity of operating with small animals such as mouse. Results: We showed that invivoPen could deliver similar efficacies as plasma activated medium with reduced cost in suppressing cell proliferation and migration as well as potentially boosting the viabilities of mice receiving invivoPen treatment. Blood test, renal and liver functionalities tests all suggest that physical plasma could effectively return tumor-carrying mice to the healthy state without harm to body conditions, and invivoPen slightly outweighs PAM in boosting animal immunity and reducing inflammation. Conclusion: Our study contributes to the community in providing a minimal invasive in situ plasma source, having partly explained the efficacies of cold atmospheric plasma in treating triple negative breast cancers, and proposing the potential synergies between physical plasma and conventional drugs for cancer treatment.
- Subjects :
- 0301 basic medicine
business.industry
plasma jet
Plasma jet
Atmospheric-pressure plasma
Inflammation
Plasma
Pharmacology
cancer treatment
Cancer treatment
03 medical and health sciences
030104 developmental biology
0302 clinical medicine
Oncology
In vivo
triple negative breast cancer
030220 oncology & carcinogenesis
Medicine
invivoPen
plasma activated medium
medicine.symptom
business
Triple negative
Triple-negative breast cancer
Research Paper
Subjects
Details
- ISSN :
- 18379664
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Cancer
- Accession number :
- edsair.doi.dedup.....f10c68dea351eb67ed4c62ba7b354e13