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Investigation of hospital discharge cases and SARS-CoV-2 introduction into Lothian care homes
Authors :
S. Cotton M.P. McHugh R. Dewar J.G. Haas K. Templeton Samuel C. Robson Thomas R. Connor Nicholas J. Loman Tanya Golubchik Rocio T. Martinez Nunez David Bonsall Andrew Rambaut Luke B. Snell Rich Livett Catherine Ludden Sally Corden Eleni Nastouli Gaia Nebbia Ian Johnston Jacqui A. Prieto Kordo Saeed David K. Jackson Catherine Houlihan Dan Frampton William L. Hamilton Adam A. Witney Giselda Bucca Cassie F. Pope Catherine Moore Emma C. Thomson Teresa Cutino-Moguel Ewan M. Harrison Colin P. Smith Fiona Rogan Shaun M. Beckwith Abigail Murray Dawn Singleton Kirstine Eastick Liz A. Sheridan Paul Randell Leigh M. Jackson Cristina V. Ariani Sónia Gonçalves Derek J. Fairley Matthew W. Loose Joanne Watkins Samuel Moses Sam Nicholls Matthew Bull Roberto Amato Darren L. Smith David M. Aanensen Jeffrey C. Barrett Beatrix Kele Dinesh Aggarwal James G. Shepherd Martin D. Curran Surendra Parmar Matthew D. Parker Catryn Williams Sharon Glaysher Anthony P. Underwood Matthew Bashton Nicole Pacchiarini Katie F. Loveson Matthew Byott Alessandro M. Carabelli Kate E. Templeton Sharon J. Peacock Thushan I. de Silva Dennis Wang Cordelia F. Langford John Sillitoe Rory N. Gunson Simon Cottrell Justin O’Grady Dominic Kwiatkowski Patrick J. Lillie Nicholas Cortes Nathan Moore Claire Thomas Phillipa J. Burns Tabitha W. Mahungu Steven Liggett Angela H. Beckett Matthew TG. Holden Lisa J. Levett Husam Osman Mohammed O. Hassan-Ibrahim David A. Simpson Meera Chand Ravi K. Gupta Alistair C. Darby Steve Paterson Oliver G. Pybus Erik M. Volz Daniela de Angelis David L. Robertson Andrew J. Page Inigo Martincorena Louise Aigrain Andrew R. Bassett Nick Wong Yusri Taha Michelle J. Erkiert Michael H. Spencer Chapman Rebecca Dewar Martin P. McHugh Siddharth Mookerjee Stephen Aplin Matthew Harvey Thea Sass Helen Umpleby Helen Wheeler James P. McKenna Ben Warne Joshua F. Taylor Yasmin Chaudhry Rhys Izuagbe Aminu S. Jahun Gregory R. Young Claire McMurray Clare M. McCann Andrew Nelson Scott Elliott Hannah Lowe Anna Price Matthew R. Crown Sara Rey Sunando Roy Ben Temperton Sharif Shaaban Andrew R. Hesketh Kenneth G. Laing Irene M. Monahan Judith Heaney Emanuela Pelosi Siona Silviera Eleri Wilson-Davies Helen Fryer Helen Adams Louis du Plessis Rob Johnson William T. Harvey Joseph Hughes Richard J. Orton Lewis G. Spurgin Yann Bourgeois Chris Ruis Áine O'Toole Marina Gourtovaia Theo Sanderson Christophe Fraser Jonathan Edgeworth Judith Breuer Stephen L. Michell John A. Todd Michaela John David Buck Kavitha Gajee Gemma L. Kay David Heyburn Themoula Charalampous Adela Alcolea-Medina Katie Kitchman Alan McNal David T. Pritch Samir Dervisevic Peter Muir Esther Robinson Barry B. Vipond Newara A. Ramadan Christopher Jeanes Danni Weldon Jana Catalan Neil Jones Ana da Silva Filipe Chris Williams Marc Fuchs Julia Miskelly Aaron R. Jeffries Karen Oliver Naomi R. Park Amy Ash Cherian Koshy Magdalena Barrow Sarah L. Buchan Anna Mantzouratou Gemma Clark Christopher W. Holmes Sharon Campbell Thomas Davis Ngee Keong Tan Julianne R. Brown Kathryn A. Harris Stephen P. Kidd Paul R. Grant Li Xu-McCrae Alison Cox Pinglawathee Madona Marcus Pond Paul A. Randell Karen T. Withell Cheryl Williams Clive Graham Rebecca Denton-Smith Emma Swindells Robyn Turnbull Tim J. Sloan Andrew Bosworth Stephanie Hutchings Hannah M. Pymont Anna Casey Liz Ratcliffe Christopher R. Jones Bridget A. Knight Tanzina Haque Jennifer Hart Dianne Irish-Tavares Eric Witele Craig Mower Louisa K. Watson DipHE Jennifer Collins Gary Eltringham Dorian Crudgington Ben Macklin Miren Iturriza-Gomara Anita O. Lucaci Patrick C. McClure Matthew Carlile Nadine Holmes Christopher Moore Nathaniel Storey Stefan Rooke Gonzalo Yebra Noel Craine Malorie Perry Nabil-Fareed Alikhan Stephen Bridgett Kate F. Cook Christopher Fearn Salman Goudarzi Ronan A. Lyons Thomas Williams Sam T. Haldenby Jillian Durham Steven Leonard Robert M. Davies Rahul Batra Beth Blane Moira J. Spyer Perminder Smith Mehmet Yavus Rachel J. Williams Adhyana IK. Mahanama Buddhini Samaraweera Sophia T. Girgis Samantha E. Hansford Angie Green Charlotte Beaver Katherine L. Bellis Matthew J. Dorman Sally Kay Liam Prestwood Shavanthi Rajatileka Joshua Quick Radoslaw Poplawski Nicola Reynolds Andrew Mack Arthur Morriss Thomas Whalley Bindi Patel Iliana Georgana Myra Hosmillo Malte L. Pinckert Joanne Stockton John H. Henderson Amy Hollis William Stanley Wen C. Yew Richard Myers Alicia Thornton Alexander Adams Tara Annett Hibo Asad Alec Birchley Jason Coombes Johnathan M. Evans Laia Fina Bree Gatica-Wilcox Lauren Gilbert Lee Graham Jessica Hey Ember Hilvers Sophie Jones Hannah Jones Sara Kumziene-Summerhayes Caoimhe McKerr Jessica Powell Georgia Pugh Sarah Taylor Alexander J. Trotter Charlotte A. Williams Leanne M. Kermack Benjamin H. Foulkes Marta Gallis Hailey R. Hornsby Stavroula F. Louka Manoj Pohare Paige Wolverson Peijun Zhang George MacIntyre-Cockett Amy Trebes Robin J. Moll Lynne Ferguson Emily J. Goldstein Alasdair Maclean Rachael Tomb Igor Starinskij Laura Thomson Joel Southgate Moritz UG. Kraemer Jayna Raghwani Alex E. Zarebski Olivia Boyd Lily Geidelberg Chris J. Illingworth Chris Jackson David Pascall Sreenu Vattipally Timothy M. Freeman Sharon N. Hsu Benjamin B. Lindsey Keith James Kevin Lewis Gerry Tonkin-Hill Jaime M. Tovar-Corona MacGregor Cox Khalil Abudahab Mirko Menegazzo Ben EW. Taylor Corin A. Yeats Afrida Mukaddas Derek W. Wright Leonardo de Oliveira Martins Rachel Colquhoun Verity Hill Ben Jackson J.T. McCrone Nathan Medd Emily Scher Jon-Paul Keatley Tanya Curran Sian Morgan Patrick Maxwell Ken Smith Sahar Eldirdiri Anita Kenyon Alison H. Holmes James R. Price Tim Wyatt Alison E. Mather Timofey Skvortsov John A. Hartley Martyn Guest Christine Kitchen Ian Merrick Robert Munn Beatrice Bertolusso Jessica Lynch Gabrielle Vernet Stuart Kirk Elizabeth Wastnedge Rachael Stanley Giles Idle Declan T. Bradley Nicholas F. Killough Jennifer Poyner Matilde Mori Owen Jones Victoria Wright Ellena Brooks Carol M. Churcher Laia Delgado Callico Mireille Fragakis Katerina Galai Andrew Jermy Sarah Judges Anna Markov Georgina M. McManus Kim S. Smith Peter MD. Thomas-McEwen Elaine Westwick Stephen W. Attwood Frances Bolt Alisha Davies Elen De Lacy Fatima Downing Sue Edwards Lizzie Meadows Sarah Jeremiah Nikki Smith Luke Foulser Amita Patel Louise Berry Tim Boswell Vicki M. Fleming Hannah C. Howson-Wells Amelia Joseph Manjinder Khakh Michelle M. Lister Paul W. Bird Karlie Fallon Thomas Helmer Claire L. McMurray Mina Odedra Jessica Shaw Julian W. Tang Nicholas J. Willford Victoria Blakey Veena Raviprakash Nicola Sheriff Lesley-Anne Williams Theresa Feltwell Luke Bedford James S. Cargill Warwick Hughes Jonathan Moore Susanne Stonehouse Laura Atkinson Jack CD. Lee Divya Shah Natasha Ohemeng-Kumi John Ramble Jasveen Sehmi Rebecca Williams Wendy Chatterton Monika Pusok William Everson Anibolina Castigador Emily Macnaughton Kate El Bouzidi Temi Lampejo Malur Sudhanva Cassie Breen Graciela Sluga Shazaad SY. Ahmad Ryan P. George Nicholas W. Machin Debbie Binns Victoria James Rachel Blacow Lindsay Coupland Louise Smith Edward Barton Debra Padgett Garren Scott Aidan Cross Mariyam Mirfenderesky Jane Greenaway Kevin Cole Phillip Clarke Nichola Duckworth Sarah Walsh Kelly Bicknell Robert Impey Sarah Wyllie Richard Hopes Chloe Bishop Vicki Chalker Ian Harrison Laura Gifford Zoltan Molnar Cressida Auckland Cariad Evans Kate Johnson David G. Partridge Mohammad Raza Paul Baker Stephen Bonner Sarah Essex Leanne J. Murray Andrew I. Lawton Shirelle Burton-Fanning Brendan AI. Payne Sheila Waugh Andrea N. Gomes Maimuna Kimuli Darren R. Murray Paula Ashfield Donald Dobie Fiona Ashford Angus Best Liam Crawford Nicola Cumley Megan Mayhew Oliver Megram Jeremy Mirza Emma Moles-Garcia Benita Percival Megan Driscoll Leah Ensell Helen L. Lowe Laurentiu Maftei Matteo Mondani Nicola J. Chaloner Benjamin J. Cogger Lisa J. Easton Hannah Huckson Jonathan Lewis Sarah Lowdon Cassandra S. Malone Florence Munemo Manasa Mutingwende Roberto Nicodemi Olga Podplomyk FD Thomas Somassa Andrew Beggs Alex Richter Claire Cormie Joana Dias Sally Forrest Ellen E. Higginson Mailis Maes Jamie Young Rose K. Davidson Kathryn A. Jackson Alexander J. Keeley Jonathan Ball Timothy Byaruhanga Joseph G. Chappell Jayasree Dey Jack D. Hill Emily J. Park Arezou Fanaie Rachel A. Hilson Geraldine Yaze Stephanie Lo Safiah Afifi Robert Beer Joshua Maksimovic Kathryn McCluggage Karla Spellman Catherine Bresner William Fuller Angela Marchbank Trudy Workma Ekaterina Shelest Johnny Debebe Fei Sang Sarah Francois Bernardo Gutierrez Tetyana I. Vasylyeva Flavia Flaviani Manon Ragonnet-Cronin Katherine L. Smollett Alice Broos Daniel Mair Jenna Nichols Kyriaki Nomikou Lily Tong Ioulia Tsatsani Sarah O'Brien Steven Rushton Roy Sanderson Jon Perkins Seb Cotton Abbie Gallagher Elias Allara Clare Pearson David Bibby Gavin Dabrer Nicholas Ellaby Eileen Gallagher Jonathan Hubb Angie Lackenby David Lee Nikos Manesis Tamyo Mbisa Steven Platt Katherine A. Twohig Mari Morgan Alp Aydin David J. Baker Ebenezer Foster-Nyarko Sophie J. Prosolek Steven Rudder Chris Baxter Sílvia F. Carvalho Deborah Lavin Arun Mariappan Clara Radulescu Aditi Singh Miao Tang Helen Morcrette Nadua Bayzid Marius Cotic Carlos E. Balcazar Michael D. Gallagher Daniel Maloney Thomas D. Stanton Kathleen A. Williamson Robin Manley Michelle L. Michelsen Christine M. Sambles David J. Studholme Joanna Warwick-Dugdale Richard Eccles Matthew Gemmell Richard Gregory Margaret Hughes Charlotte Nelson Lucille Rainbow Edith E. Vamos Hermione J. Webster Mark Whitehead Claudia Wierzbicki Adrienn Angyal Luke R. Green Max Whiteley Emma Betteridge Iraad F. Bronner Ben W. Farr Scott Goodwin Stefanie V. Lensing Shane A. McCarthy Michael A. Quail Diana Rajan Nicholas M. Redshaw Carol Scott Lesley Shirley Scott AJ. Thurston Will Rowe Amy Gaskin Thanh Le-Viet James Bonfield Jennifier Liddle Andrew Whitwham University of St Andrews. School of Medicine University of St Andrews. Infection and Global Health Division Apollo - University of Cambridge Repository
Publication Year :
2023
Abstract
COG-UK is supported by funding from the MRC part of UK Research & Innovation, the National Institute of Health Research (Grant code MC_PC_19027), and Genome Research Limited, operating as the Welcome Sanger Institute. Background The first epidemic wave of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in Scotland resulted in high case numbers and mortality in care homes. In Lothian, over one-third of care homes reported an outbreak, while there was limited testing of hospital patients discharged to care homes. Aim To investigate patients discharged from hospitals as a source of SARS-CoV-2 introduction into care homes during the first epidemic wave. Methods A clinical review was performed for all patients discharges from hospitals to care homes from 1st March 2020 to 31st May 2020. Episodes were ruled out based on coronavirus disease 2019 (COVID-19) test history, clinical assessment at discharge, whole-genome sequencing (WGS) data and an infectious period of 14 days. Clinical samples were processed for WGS, and consensus genomes generated were used for analysis using Cluster Investigation and Virus Epidemiological Tool software. Patient timelines were obtained using electronic hospital records. Findings In total, 787 patients discharged from hospitals to care homes were identified. Of these, 776 (99%) were ruled out for subsequent introduction of SARS-CoV-2 into care homes. However, for 10 episodes, the results were inconclusive as there was low genomic diversity in consensus genomes or no sequencing data were available. Only one discharge episode had a genomic, time and location link to positive cases during hospital admission, leading to 10 positive cases in their care home. Conclusion The majority of patients discharged from hospitals were ruled out for introduction of SARS-CoV-2 into care homes, highlighting the importance of screening all new admissions when faced with a novel emerging virus and no available vaccine. Publisher PDF
Details
Language :
English
Database :
OpenAIRE
Accession number :
edsair.doi.dedup.....f10bfee06cd07deff1c979a8392cf6e1